Catastrophizing, Kinesiophobia, and Acceptance as Mediators of the Relationship Between Perceived Pain Severity, Self-Reported and Performance-Based Physical Function in Women with Fibromyalgia and Obesity

ORIGINAL RESEARCH Catastrophizing, Kinesiophobia, and Acceptance as Mediators of the Relationship Between Perceived Pain Severity, Self-Reported and Performance-Based Physical Function in Women with Fibromyalgia and Obesity Giorgia Varallo 1 , Carlos Suso-Ribera 2 , Ada Ghiggia 3 , Marco Veneruso 4 , Roberto Cattivelli 5 , Anna Guerrini Usubini 6,7 , Christian Franceschini 1 , Alessandro Musetti 8 , Giuseppe Plazzi 9,10 , Jacopo Maria Fontana 11 , Paolo Capodaglio 11,12 , Gianluca Castelnuovo 6,7 1 Department of Medicine and Surgery, University of Parma, Parma, 43121, Italy; 2 Department of Basic and Clinical Psychology and Psychobiology, Jaume I University, Castellon de la Plana, 12071, Spain; 3 Department of Life Sciences, University of Trieste, Trieste, 34127, Italy; 4 Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy; 5 Department of Psychology, University of Bologna, Bologna, 40127, Italy; 6 Department of Psychology, Catholic University of Milan, Milan, 20123, Italy; 7 Istituto Auxologico Italiano IRCCS, Psychology Research Laboratory, San Giuseppe Hospital, Verbania, 28824, Italy; 8 Department of Humanities, Social Sciences and Cultural Industries, University of Parma, Parma, 43125, Italy; 9 Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, 41125, Italy; 10 IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, 40139, Italy; 11 Istituto Auxologico Italiano IRCCS, Orthopaedic Rehabilitation Unit and Research Laboratory in Biomechanics and Rehabilitation, San Giuseppe Hospital, Verbania, 28824, Italy; 12 Department of Surgical Sciences, Physical and Rehabilitation Medicine, University of Turin, Turin, 10121, Italy Correspondence: Jacopo Maria Fontana, San Giuseppe Hospital, Strada Cadorna 90, Verbania, 28824, Italy, Tel +39 0323 514 331, Email [email protected] Purpose: Individuals with fibromyalgia and obesity experience significant impairment in physical functioning. Pain catastrophizing, kinesiophobia, and pain acceptance have all been identified as important factors associated with the level of disability. The objective of this study was to evaluate the role of pain catastrophizing, kinesiophobia, and pain acceptance as mediators of the association between perceived pain severity and physical functioning in individuals with fibromyalgia and obesity. Patients and Methods: In this cross-sectional study, 165 women with fibromyalgia and obesity completed self-report questionnaires of perceived pain severity (ie, Numeric Pain Rating Scale), pain catastrophizing (ie, Pain Catastrophizing Scale), kinesiophobia (ie Tampa Scale of Kinesiophobia), pain acceptance (ie, Chronic Pain Acceptance Questionnaire), and perceived physical functioning (ie, Physical Functioning subscale of the Fibromyalgia Impact Questionnaire). In addition, a performance-based test (ie, 6-minute walking test) was conducted to assess objective physical functioning. Two multiple mediation analyses were performed. Results: Pain acceptance and kinesiophobia mediated the relationship between pain severity and self-reported physical functioning. Pain catastrophizing and kinesiophobia mediated the relationship between pain severity and performance-based functioning. Conclusion: Pain acceptance, kinesiophobia, and pain catastrophizing should be addressed in rehabilitative intervention to improve physical functioning. Interestingly, the subjective and objective aspects of physical functioning are influenced by different factors. Therefore, interventions for women with fibromyalgia and obesity should focus on factors related to both subjective and performance-based physical functioning. Keywords: chronic pain, fear-avoidance model, fibromyalgia, functioning, obesity, psychological flexibility model Plain Language Summary Our work highlights how psychological factors (ie, pain catastrophizing, kinesiophobia, and pain acceptance) explain the association between pain severity and physical functioning. Interestingly, the relationship between pain intensity and different aspects of physical functioning (ie, self-reported and performance-based physical functioning) is associated with different psychological factors. Pain Journal of Pain Research 2022:15 3017–3029 3017 © 2022 Varallo et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Journal of Pain Research Dovepress open access to scientific and medical research Open Access Full Text Article Received: 26 April 2022 Accepted: 18 August 2022 Published: 26 September 2022 Journal of Pain Research downloaded from https://www.dovepress.com/ on 17-Feb-2023 For personal use only. acceptance and kinesiophobia explain the relationship between pain severity and self-reported physical functioning (ie, what I think I can do). Whereas, pain catastrophizing and kinesiophobia explain the relationship between pain severity and performance-based functioning (ie, what I can actually do). Our results could inform the development of interventions aimed at improving physical functioning both in its self-reported and in its performance-based dimension. Introduction Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread and persistent pain, fatigue, poor sleep quality, cognitive problems, and mood disturbances. 1 FM has a negative impact on the quality of life 2 and severely impairs physical functioning. 3 The etiology of FM is unclear and multifaceted, and it appears that a complex intertwining of genetic, biological, and psychological factors plays a role in its development and maintenance. 4 Impaired physical functioning is one of the most challenging consequences of FM, especially when there is comorbid obesity. 5 Obesity has a high prevalence in FM 5–7 and further contributes to functional disability. 5,8,9 Higher levels of BMI are associated with increased pain intensity, decreased quality of life, and higher levels of disability in patients with FM. 5 Notably, pain and fatigue associated with FM can lead to sedentary behavior, physical inactivity, and weight gain, which can, in turn, exacerbate both conditions. 10 Impairments in physical functioning are associated with the severity of perceived pain; 11–13 however, evidence showed that reducing pain intensity does not result in a proportional improvement in physical functioning. 14–17 Inconsistencies in the relationship between pain severity and physical functioning suggest that this association may be mediated by other factors. 18 The biopsychosocial approach has emphasized the role of psychological factors in the development and maintenance of chronic pain and associated disabilities. 19 Indeed, cognitive, affective, and behavioral factors contribute to pain severity and disability in chronic pain conditions, 20–24 including FM. 25,26 The Fear Avoidance Model 22 and the Psychological Flexibility Model 27,28 are two of the most well-known models that describe the progression of transient pain into persistent pain and explain why chronic pain occurs only in a subset of individuals who have experienced acute pain. According to the Fear Avoidance Model, pain catastrophizing and kinesiophobia are two cognitive-affective pain responses that contribute to the development of chronic pain and associated disability. 23,24,26,29,30 This model posits that individuals who cognitively evaluate pain as catastrophic and experience pain-related fear may engage in avoidance of movement and activities associated with pain. 31,32 Avoidance behaviors eventually contribute to physical impairments, increased disability and pain chronification. 33,34 Pain catastrophizing is defined as an exaggerated and negative appraisal of pain that occurs in response to actual or anticipated pain experiences. 35,36 People who are prone to pain catastrophization magnify the threat value of pain, ruminate about pain episodes, and feel helpless. Kinesiophobia, on the other hand, refers to an excessive, irrational, and debilitating fear of physical movement and activity resulting from a feeling of vulnerability due to a painful injury or reinjury. 37 According to the Psychological Flexibility Model, 38 pain acceptance is defined as the willingness to live with pain without trying to reduce, avoid, or change it, 27 meaning that individuals are willing to engage in valued activities and focus on personal goals and values despite the presence of chronic pain. Importantly, these two models posit that the psychological response to pain determines, at least in part, the level of disability, not just the intensity of pain. Thus, pain catastrophizing and kinesiophobia create a negative trajectory that leads to disability, whereas pain acceptance creates a positive trajectory that leads to improved functioning despite pain. 39,40 Pain catastrophizing and kinesiophobia have been consistently reported in individuals with FM 25,26,41–43 and have been associated with both higher pain intensity and reduced physical functioning in FM 26,43 and other pain conditions. 24,25,30,44–46 Whereas, lower pain acceptance is associated with increased pain intensity, higher levels of disability, and poorer physical functioning. 47 These findings suggest that people with higher levels of pain severity may experience higher levels of pain catastrophization and kinesiophobia, as well as reduced acceptance, resulting in avoidance of movement and activities. 48 Evidence reported higher levels of pain catastrophizing in individuals with severe obesity and osteoarthritis compared with individuals with less severe degrees of obesity and overweight. 49 Similarly, kinesiophobia levels were found to be higher in patients with chronic low back and knee pain-related diagnoses with obesity compared to those without. 50,51 With respect to pain acceptance in chronic pain conditions with comorbid obesity, the evidence is sparse. To our knowledge, there is only a recent study conducted by our group that found an association between lower levels of pain https://doi.org/10.2147/JPR.S370718 DovePress Journal of Pain Research 2022:15 3018 Varallo et al Dovepress Powered by TCPDF (www.tcpdf.org)Powered by TCPDF (www.tcpdf.org) acceptance and poorer physical functioning in patients with FM and obesity. 25 In sum, individuals with chronic pain and obesity who exhibit higher levels of pain catastrophizing, kinesiophobia, and lower levels of pain acceptance in response to pain, may reduce physical activity and movement. This might lead to physical deconditioning and disuse, which contribute to increased pain, greater disability, and potentially additional weight gain 10 perpetuating the vicious cycle. Studies regarding the physical consequences of chronic pain and the impact of psychological factors on disability are numerous and have provided important insights in the past decades. 52 However, most studies on physical functioning in individuals with chronic pain, including FM, have focused on self-reported (ie, subjective perception) measures. Even though this is an important aspect to consider, it appears that there might be a mismatch between self-reported and performance-based physical functioning (eg, six-minute walking test). Indeed, it has been suggested that these two types of measures provide different and complementary information. 53 The novelty of the present study is that, following the Initiative on Methods, Measurement and Pain Assessment in Clinical Trials (IMPAACT) guidelines, 54 physical functioning is assessed by taking into account both self-reported and performance-based measures. We aimed to investigate psychological mediators in the pain-to-physical functioning relationship using both measures of physical status, in order to develop tailored treatments according to the outcome targeted (ie, self-reported or performance-based physical functioning). To our knowledge, this is the first study to explore the mediating effects of multiple psychological factors, such as pain catastrophizing, kinesiophobia, and pain acceptance, on the association between pain severity and both self-reported and performance-based physical functioning in individuals with FM and obesity. Based on previous results on patients with chronic low back pain, 24 heterogeneous chronic pain, 55,56 and FM, 26 we hypothesized that pain catastrophizing, kinesiophobia, and pain acceptance would mediate the relationship between pain severity and physical functioning. The mediators’ differential contributions to self-reported and performance-based physical functioning will be evaluated in an exploratory manner because there is insufficient evidence to support any hypothesis. Materials and Methods A cross-sectional study was performed. We consecutively recruited, by convenience sampling, 165 participants at the beginning of a one-month hospitalization for physical rehabilitation and weight loss. The recruitment at the Istituto Auxologico Italiano began in January 2019 and ended in October 2019. Data were collected during the first week of diagnostic assessment, before the start of any physical therapy and nutritional intervention. The study was conducted according to the guidelines of the Declaration of Helsinki of 1975, as revised in 1983, and approved by the Ethics Committee of Istituto Auxologico Italiano. The present study is a secondary data analysis of this data collection that resulted in a published article. 25 Participants were eligible if they met the following criteria: (a) had previously been diagnosed with FM by a rheumatologist; 1 (b) met the American College of Rheumatology (ACR) Research Criteria, 57,58 as measured by the Fibromyalgia Survey Questionnaire; 59 (c) were between the ages of 18 and 65; and (d) could sign an informed consent form. Patients were excluded if they (a) had psychiatric disorders with psychotic symptoms; (b) had a diagnosed personality disorder; (c) had previously received psychological intervention for FM management; (d) or had comorbid acute or chronic pain conditions other than FM. Measures Participants completed a self-report form with sociodemographic information including age, weight (in kilograms), and height (in centimeters) that were used to calculate the Body Mass Index (BMI; kg/m2). Predictor The Numeric Pain Rating Scale (NPRS) was used to assess pain severity. This is a validated and widely used measure of pain severity in chronic pain conditions. It is composed of an 11-point scale where 0 = “no pain” and 10 = “worst possible pain”. 60 Journal of Pain Research 2022:15 https://doi.org/10.2147/JPR.S370718 DovePress 3019 Dovepress Varallo et al Powered by TCPDF (www.tcpdf.org)Powered by TCPDF (www.tcpdf.org) Mediators The Pain Catastrophizing Scale (PCS) 35 is a measure of catastrophic thinking about pain. It includes 13 items on a fivepoint Likert scale, with responses ranging from 0 = “not at all” to 4 = “all the time”. The total score ranges from 0 to 52, with higher scores corresponding to higher levels of pain catastrophizing. 61 The Italian version 61 has psychometric properties similar to the original version. Internal consistency was excellent in the current study (Cronbach’s α = 0.90). The Chronic Pain Acceptance Questionnaire (CPAQ) is a self-report measure of pain acceptance. 38,62,63 It consists of 20 items on a 7-point Likert scale, from 0= “never true” to 6= “always true”. The maximum total score is 120, with higher scores corresponding to higher pain acceptance. The Italian version of the questionnaire 64 has psychometric properties consistent with the original English version. In the present study, the internal consistency of this measure was excellent (Cronbach’s α = 0.89). The Italian version 65 of the Tampa Scale of Kinesiophobia (TSK) 65 was used to assess kinesiophobia. The TSK consists of 13 items ranging from “strongly disagree” to “strongly agree”, on a 4-point Likert scale. 66 The total score ranges from 13 to 52, and higher scores indicate higher levels of kinesiophobia. 65 The Italian version of the TSK shows a good factorial structure and acceptable psychometric properties. 65 In the current study, the internal consistency of this measure was excellent (Cronbach’s α = 0.90). Outcomes The FIQR is a 21-item measure that uses a numerical rating scale of 0 to 10, with 10 corresponding to higher levels of disability. All questions refer to the functioning during the previous seven days. The FIQR evaluates three domains: (a) “physical function”, (b) “overall impact”, and (c) “symptoms”. The total score measures the impact of FM on overall functioning, with higher total scores indicating a greater impact of the disease and poorer functioning. Given the purpose of the current study, the Physical Functioning subscale was used to assess self-reported disability (PF-FIQR). The PFFIQR includes nine items that assess the degree of physical impairment. This scale has previously been used in research. 67–70 The physical functioning subscale of the FIQR has a score range of 0 to 30, with higher scores indicating poorer physical functioning. The Italian version of the FIQR 71 has good psychometric properties in line with the original version. 72 In the current study, the internal consistency of the scale was good (Cronbach’s α = 0.82). The 6-minute walking test (6MWT) is a performance-based measure of physical functioning. The 6MWT has been used in research with FM patients 68,70,73 with good applicability and reliability. 68,74 The participant is required to walk for six minutes along a rectangular course of 45.7 m. The walking distance is measured in meters. Higher scores indicate better physical functioning. The distance walked during 6MWT appears to reflect the ability to perform daily living activities 75,76 and was found to be shorter in female FM patients compared to healthy women. 77 Furthermore, the 6MWT has good reproducibility and is recommended for evaluating walking ability in individuals with obesity. 78 Statistical Analysis Descriptive statistics, including ranges, means, and standard deviations are presented in Table 1. According to Fritz and Mackinnon, 79 our sample size is sufficient for performing a mediation analysis with small-to-medium (0.26) a path and b paths with a 0.80 power. Preliminary analyses were conducted to check multicollinearity using Pearson’s correlations. Pearson’s correlation coefficients were also used to assess potential confounders. The level of significance of Pearson’s correlations was adjusted for multiple comparisons with Bonferroni correction (ie, α ≤ 0.05/10= p ≤ 0.005). To control for confounding variables, sociodemographic and clinical characteristics that showed significant associations with the outcome variable in bivariate analyses were planned to be included in the multiple mediation analysis. We performed two multiple mediation models. In the first model (see Figure 1), we evaluated pain catastrophizing, pain acceptance, and kinesiophobia as mediators (ie, M) of the relationship between pain severity (ie, X) and selfreported physical functioning (ie, Y). In the second model (see Figure 2), we evaluated pain catastrophizing, pain acceptance, and kinesiophobia as mediators of the relationship between pain severity and performance-based physical functioning. In the mediation analyses, we calculated direct, indirect, and total effects. 80 The effect of X (ie, pain severity) on Y (ie, physical functioning) is referred to as the direct effect (c’ path). The effect of X on Y via M (ie, pain catastrophizing, pain acceptance, kinesiophobia) is referred to as the indirect effect (ab path). The path a represents the https://doi.org/10.2147/JPR.S370718 DovePress Journal of Pain Research 2022:15 3020 Varallo et al Dovepress Powered by TCPDF (www.tcpdf.org)Powered by TCPDF (www.tcpdf.org) effect of X on M, whereas path b is the effect of M on Y when controlling for the effect of X. Lastly, we determined the total effect of X on Y (c path), which is the sum of direct and indirect effects. The paths were quantified with both unstandardized (B) and standardized (β) regression coefficients. To test the significance of indirect effects, bias-corrected bootstrap confidence intervals (BC-CI) were calculated following the procedures recommended by Preacher and Hayes. 80 The bootstrap estimates were based on 5000 bootstrap samples. 81 A 95% CI was used. Significant effects are those in which the confidence interval does not contain zero. Mediation analyses were conducted using the PROCESS macro for SPSS version 27.0. 82,83 Results Participants’ Characteristics Overall, 165 individuals were included in this study. Table 1 shows the demographic and clinical characteristics of the participants, as well as the means, standard deviations, and ranges for the main measures. Table 1 Means and Standard Deviations of the Sociodemographic and Clinical Measures Sociodemographic Factors N=165 Mean ± SD Age in years (mean± SD) 43.8±7.26 Body Mass Index (mean± SD) 44.4±7.22 Pain duration in years (mean± SD) 7.13±2.71 Current opioid use (%) 20% Clinical factors Theoretical range Actual range Mean ± SD Numeric Pain Rating Scale 0–10 3–10 5.71±1.59 Pain Catastrophizing Scale 0–52 0–44 26.9±10.7 Chronic Pain Acceptance Questionnaire 0–120 21–74 51.5±11.5 Tampa Scale of Kinesiophobia 13–52 23–52 38.8±9.05 Physical functioning subscale 0–30 9–29 17.8±4.75 6-Minute Walking Test NA 201–402 304±59.8 Figure 1 Conceptual diagram of the first mediation model. *p<0.05, **p<0.01, ***p<0.001. Journal of Pain Research 2022:15 https://doi.org/10.2147/JPR.S370718 DovePress 3021 Dovepress Varallo et al Powered by TCPDF (www.tcpdf.org)Powered by TCPDF (www.tcpdf.org) Pearson Correlation Analyses Correlation analyses were performed for all study variables (see Table 2). Correlation coefficients were interpreted according to Cohen 84 (0.10=small; 0.30=medium; 0.50=large). Pain catastrophizing showed positive and moderate correlations with pain severity (r= 0.38, p<0.001), self-reported disability (r=0.44, p<0.001), and kinesiophobia (r=0.55, p<0.001), as well as negative and strong correlations with pain acceptance (r=−.52, p<0.001) and negative strong correlations with performance-based physical functioning (r=−.57, p<0.001). Kinesiophobia showed a moderate and positive correlation with pain intensity (r= 0.46, p<0.001) and a positive and strong correlation with self-reported physical functioning (r=0.54, p<0.001). On the contrary, kinesiophobia was negatively and strongly correlated with pain acceptance (r=−.64, p<0.001) and performance based-physical functioning (r=−.70, p<0.001). Pain acceptance was positively and moderately correlated with performance-based physical functioning (r=0.54, p<0.001), while negatively and moderately correlated with pain severity (r=−.39, p<0.001) and self-reported disability (r=−.50, p<0.001). Because none of the demographic and clinical variables (ie, BMI, pain duration, opioid use) were significantly correlated with outcomes (see Table 2), no covariates were included in the model. Figure 2 Conceptual diagram of the second mediation model. **p<0.01, ***p<0.001. Table 2 Bonferroni Adjusted Correlations Matrix for Study Variables 1. 2. 3. 4. 5. 6. 7. 8. 9. 1. Age – 2. BMI 0.03 – 3. Pain duration 0.03 0.03 – 4. Opioid use 0.17 0.10 −0.14 – 5. NPRS −0.01 0.21 −0.08 0.03 – 6. PCS 0.09 0.20 0.05 −0.05 0.38* – 7. CPAQ −0.07 −0.19 −0.07 0.01 −0.39* −0.52* – 8. TSK 0.12 0.26* 0.09 0.06 0.46* 0.55* −0.64* – 9. PF-FIQR 0.06 0.031 −0.03 0.04 0.35* 0.44* −0.50* 0.54* - 10. 6MWT −0.87 −0.16 −0.02 −0.12 −0.40 −0.57* 0.54* −0.70* −0.54* Note: *Bonferroni adjusted 2-sided significance level of α ≤ 0.05/10= p ≤ 0.005. Abbreviations: BMI, Body Mass Index; NPRS, Numeric Pain Rating Scale; PCS, Pain Catastrophizing Scale; CPAQ, Chronic Pain Acceptance Questionnaire; TSK, Tampa Scale of Kinesiophobia; PF-FIQ, Physical Functioning subscale of the Fibromyalgia Impact Questionnaire; 6MWT, 6 Minute Walking Test. https://doi.org/10.2147/JPR.S370718 DovePress Journal of Pain Research 2022:15 3022 Varallo et al Dovepress Powered by TCPDF (www.tcpdf.org)Powered by TCPDF (www.tcpdf.org) Mediation Analyses Pain catastrophizing, pain acceptance, and kinesiophobia were tested in two multiple mediation models to explore their overall indirect effect and their contributions to the relationship between pain severity and self-reported and performancebased physical functioning. The results are presented in Table 3. Regarding self-reported physical functioning, there is a significant indirect effect of pain severity through pain acceptance (B=0.24, SE=0.12, LLCI=0.05, ULCI=0.53) and kinesiophobia (B=0.40, SE=0.14, LLCI=0.15, ULCI=0.69) and a significant total effect of pain severity through mediators (B=1.05, SE=0.22, LLCI=0.62, ULCI=1.47). However, the direct effect was not significant (B = 0.24, SE = 0.20, LLCI = −0.12, ULCI = 0.64), indicating full mediation. In relation to performance-based functioning, we found a significant indirect effect of pain severity via pain catastrophizing (B=−3.33, SE=1.38, LLCI=−6.73, ULCI=−1.18) and kinesiophobia (B=−8.26, SE=1.50, LLCI=−11.46, ULCI=−5.58) and a significant total effect of pain severity via the mediators (B=−14.85, SE=2.69, LLCI=−20.13, ULCI=−9.56). The direct effect was non-significant (B=−1.85, SE= 2.25, LLCI=−6.12, ULCI= 2.75), indicating full mediation. Discussion The goal of our study was to explore the mediating roles of pain catastrophizing, kinesiophobia, and pain acceptance in the relationship between pain severity and both self-reported and performance-based physical functioning. According to our results: i) pain acceptance and kinesiophobia mediated the relationship between pain severity and self-reported physical functioning; b) pain catastrophizing and kinesiophobia mediated the relationship between pain severity and performanceTable 3 Mediation Estimates of Pain Severity on Self-Reported Physical and Performanace Based Functioning Through Pain Catastrophizing, Pain Acceptance, and Kinesiophobia Indirect effect of pain severity on self-reported physical functioning via the mediators B SE LLCI ULCI β Pain catastrophizing 0.16 0.12 −0.03 0.43 0.06 Pain acceptance 0.24 0.12 0.05 0.53 0.08 Kinesiophobia 0.40 0.14 0.15 0.69 0.14 Direct effect of pain severity on self-reported physical functioning B SE LLCI ULCI β 0.24 0.20 −0.12 0.64 0.09 Total effect of pain severity on self-reported physical functioning via mediators B SE LLCI ULCI β 1.05 0.22 0.62 1.47 0.35 Indirect effect of pain severity on performance-based physical functioning via the mediators B SE LLCI ULCI β Pain catastrophizing −3.33 1.38 −6.73 −1.18 −0.09 Pain acceptance −1.40 1.12 −4.03 0.51 −0.04 Kinesiophobia −8.26 1.50 −11.46 −5.58 −0.24 Direct effect of pain severity on performance-based physical functioning B SE LLCI ULCI β −1.85 2.25 −6.12 2.75 −0.05 Total effect of pain severity on performance-based physical functioning via mediators B SE LLCI ULCI β −14.84 2.69 −20.13 −9.56 −0.40 Abbreviations: B, unstandardized beta; SE, standard error; LLCI, 95% lower limit confidence interval; ULCI, 95% upper limit confidence interval; β, standardized beta. Journal of Pain Research 2022:15 https://doi.org/10.2147/JPR.S370718 DovePress 3023 Dovepress Varallo et al Powered by TCPDF (www.tcpdf.org)Powered by TCPDF (www.tcpdf.org) based functioning; c) kinesiophobia had a greater mediating effect on both self-reported and performance-based functioning compared with the other mediators. Overall, these findings support the idea that pain severity impacts the physical functioning of people with FM and obesity via psychological factors. Importantly, the relationship between pain severity, self-reported and performance-based physical functioning was mediated by different factors. Concerning self-reported functioning, our results are consistent with previous findings in individuals with chronic low-back pain and obesity, in which kinesiophobia mediated the relationship between pain severity and disability. 24 They are also consistent with the results of other cross-sectional studies that explored this relationship in individuals with chronic low-back pain 16,85 and whiplash injury. 86 Our results regarding pain acceptance are also in line with previous evidence. For example, pain acceptance significantly mediated the relationship between pain severity and self-reported performance of valued activities in individuals with rheumatoid arthritis. 87 However, in another study, pain acceptance did not result as a significant mediator of the relationship between pain severity and self-reported functioning in a sample of individuals with FM. 41 However, these differences could be explained by the different outcomes measured. Indeed, in this previous study, the outcome was the impact of FM (ie, the total score of the Fibromyalgia Impact Questionnaire). Differently, we used the self-reported physical functioning subscale of the Fibromyalgia Impact Questionnaire. Our results suggest that kinesiophobia and acceptance might explain the influence of pain severity on self-reported disability. Therefore, experiencing a higher level of pain might lead to greater fear of movement and lower acceptance of the pain experience, resulting in greater self-reported disability. Interestingly, the full mediation indicates that kinesiophobia and pain acceptance account for all the observed relationship between pain severity and self-reported physical functioning. Pain catastrophizing did not result as a significant mediator of the relationship between pain severity and self-reported functioning. This finding is surprising because pain catastrophizing is one of the most consistent predictors of self-reported disability in chronic pain, and previous evidence confirmed its mediating role. 26 However, in a study conducted by Lami et al, the authors did not find a significant mediating effect of catastrophizing in the relationship between pain severity and self-reported FM impact. 41 Previous results in individuals with chronic low back pain and obesity found that kinesiophobia, but not pain catastrophizing, was associated with self-reported disability. 30,88 Also, it is important to note that most research did not include individuals with comorbid obesity and, importantly, did not account for the contribution of other significant additional mediators. 26,89,90 Finally, because psychosocial factors tend to be intercorrelated, predictive models in chronic pain should account for this shared variance between predictors to develop parsimonious models of pain and disability. 91 The fact that the present study included three important psychological predictors of disability might explain why not all of them contributed unique variance to physical performance. The relationship between pain severity and performance-based physical functioning was fully mediated by kinesiophobia and pain catastrophizing, but not by pain acceptance. Thus, higher pain severity negatively impacts physical performance through higher levels of catastrophizing and kinesiophobia. These results support the idea that, during the 6minute walking test, the psychological evaluation and response to potential harm and pain worsening due to movement might play a prominent role. Pain is a prominent and attention-demanding signal that prompts protective action to avoid or minimize its impact. 92 Thus, pain catastrophizing and kinesiophobia might serve a protective function against pain and its worsening by encouraging avoidance and restriction of movement. It is possible that a repertoire of protective cognitive/affective responses, including pain catastrophizing and kinesiophobia, leads to safety-seeking behavior such as avoidance of activities, as suggested in the Fear Avoidance Model. 93 These protective behaviors are functional in the case of acute pain, but paradoxically increase disability in chronic pain by avoiding confrontation with the pain. Kinesiophobia was the only significant mediator of the relationship between pain severity and both self-reported and performance-based disability. Another interesting finding was that kinesiophobia had a greater weight than other psychological factors in both models. Obesity might play a central role in the explanation of these results. Indeed, this condition imposes additional limitations on movements, such as respiratory difficulty, discomfort, and skin friction. 94 Thus, individuals with FM and obesity may develop a greater fear of movement. 43 However, targeting fear of movement in this population might have a dual health benefit. Indeed, physical activity improves physical functioning in chronic pain; 95,96 and it is an essential component of weight loss programs. 97 Reducing kinesiophobia may improve adherence to physical activity regimens (which are often inadequate in both patients with chronic pain 98 and obesity), 99,100 with positive effects in both conditions. https://doi.org/10.2147/JPR.S370718 DovePress Journal of Pain Research 2022:15 3024 Varallo et al Dovepress Powered by TCPDF (www.tcpdf.org)Powered by TCPDF (www.tcpdf.org) Overall, it appears that pain catastrophizing, kinesiophobia, and pain acceptance should be key therapeutic targets in the interdisciplinary treatment of people with FM and obesity to improve self-reported and performance-based physical functioning. The impact of pain severity on physical functioning may be minimized by reducing pain catastrophizing and kinesiophobia and increasing pain acceptance. An important additional finding was that our results supported the full mediation of psychological factors, which suggests that the selected mediators were relevant. While acknowledging this, it is important to note that the list of potential mediators is far from complete. We did not measure the level of depressive symptomatology. Indeed, depression has a significant impact on physical performance. 101 Additionally, depression and pain catastrophizing are two constructs that are frequently overlapped and associated. 44,102 Kinesiophobia 103 and acceptance 102 also seem to be associated with depression. The inclusion of depression in future mediation models could result in interesting novel findings. Our results might have several clinical implications. Interventions aimed at improving physical functioning should include not only pain reduction interventions but also interventions aimed at modifying cognitive and affective responses to pain. Furthermore, our findings support the idea that different aspects of physical functioning are influenced by different factors. Therefore, clinicians should prioritize the factors related to the specific aspects of physical functioning targeted in the intervention. Kinesiophobia might be relevant for both objective and subjective physical performance, while acceptance and catastrophizing would be more relevant for self-report and performance-based physical functioning, respectively. A strength of the present study is the combination of factors from two different models of pain, namely, the Fear Avoidance Model (ie, kinesiophobia and pain catastrophizing) and the Psychological Flexibility Model (ie, pain acceptance). According to our findings, combining the two models could be beneficial because factors from both the Fear Avoidance Model and the Psychological Flexibility Model contributed independently to the mediation model. Interventions that combine therapeutic strategies from Cognitive Behavioral Therapy and Acceptance and Commitment Therapy may be a valuable option for patients with obesity and FM. 41,104 Several limitations must be discussed. The cross-sectional design of the study prevents us from drawing causality conclusions. Furthermore, some potentially confounding factors (eg, anxiety and depression) were not assessed. The use of a single measurement may not be ideal in chronic pain conditions such as fibromyalgia, in which pain has a wide variability within and between days. An ecological momentary assessment design could provide reliable data. 105 Conclusion Pain acceptance and kinesiophobia appear to be significant mediators of the relationship between pain severity and selfreported physical functioning. On the other hand, pain catastrophizing and kinesiophobia had a mediating effect on the relationship between pain severity and performance-based functioning. Thus, the relationship between pain severity and different aspects of physical functioning appears to be mediated by different psychological factors. Psychological interventions targeting these factors should be included in multidisciplinary rehabilitation programs for people with FM and obesity. By reducing pain catastrophizing and kinesiophobia and improving pain acceptance, the effect of pain severity on physical functioning could be mitigated. Abbreviations 6MWT, Six Minute Walking Test; ACR, American College of Rheumatology; BC-CI, Bias Corrected Confidence Interval; CPAQ, Chronic Pain Acceptance Questionnaire; FIQR, Fibromyalgia Impact Questionnaire Revised; FM, Fibromyalgia; IMMPACT, Initiative on Methods, Measurement and Pain Assessment in Clinical Trials; NPRS, Numeric Pain Rating Scale; PCS, Pain Catastrophizing Scale; PF-FIQR, Physical Functioning subscale of Fibromyalgia Impact Questionnaire Revised; TSK, Tampa Scale of Kinesiophobia. Author Contributions All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; agreed to submit to the current journal; gave final approval of the version to be published; and agree to be accountable for all aspects of the work. Journal of Pain Research 2022:15 https://doi.org/10.2147/JPR.S370718 DovePress 3025 Dovepress Varallo et al Powered by TCPDF (www.tcpdf.org)Powered by TCPDF (www.tcpdf.org)