65
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
OPTIMIZATION OF EXTRACT PRODUCTION FROM CURCUMA LONGA
Ismoilo Sh.F.1
Kayumo F.S.2
Tashken Pha maceu ical Ins i u e, Tashken ci y, Republic o Uzbekis an
e-mail: shoh ux. a uxo [email protected]
h ps://doi.o g/10.5281/zenodo.17318438
Rele ance: phy o he apy based on medicinal plan s is one o he oldes he apeu ic p ac ices in
human his o y and s ill holds an impo an place in mode n medicine. Today, he e is an inc easing
demand o na u al p epa a ions ha a e ecologically sa e, low in oxici y, and highly biologically
ac i e. In pa icula , he use o medicinal plan s ich in la onoids and o he bioac i e compounds is
widesp ead in he p e en ion and ea men o li e diseases. One such plan is Cu cuma longa
( u me ic), whose main bioac i e subs ances — cu cumin and la onoids — possess an ioxidan , an i-
in lamma o y, an icance , and hepa op o ec i e p ope ies. T adi ional ex ac ion me hods a e o en
ime-consuming and ene gy-in ensi e, and may no ensu e su icien yields o bioac i e compounds.
The e o e, ul asonic ex ac ion echnology is o pa icula impo ance due o i s e iciency and
ene gy-sa ing ad an ages.
Aim o he s udy: he main aim o he esea ch is o de elop a echnology o ob aining d y
ex ac ich in bioac i e compounds om Cu cuma longa using ul asonic ex ac ion, o de e mine
he op imal sol en sys em, o e alua e he e iciency o he ex ac ion p ocess, and o s udy he
physicochemical and echnological p ope ies o he esul ing d y ex ac .
Ma e ials and Me hods: he hizomes o Cu cuma longa we e used as aw ma e ial. Va ious
sol en s pu i ied wa e , 50% e hanol, and 70% e hanol we e es ed o ex ac ion. Ul asonic ba h
ex ac ion was ca ied ou o 15, 30, 45, and 60 minu es. Di e en aw ma e ial- o-sol en a ios
( anging om 1:2 o 1:7) we e examined o iden i y he mos e ec i e p opo ion. The ob ained liquid
ex ac s we e cen i uged o emo e ballas subs ances, hen d ied unde acuum a 105±5 °C o
p oduce a d y ex ac . The p oduc was e alua ed o mois u e con en , pa icle size, lowabili y, bulk
densi y, g anulome ic composi ion, and angle o epose, in o de o assess i s pha maceu ical
applicabili y.
Resul s: acco ding o he s udy esul s, ul asonic ex ac ion a 40–50 °C and a aw ma e ial-
o-sol en a io o 1:6 p o ided he mos e icien ou come. Among he es ed sol en s, 50% e hanol
demons a ed he highes ex ac ion yield o bioac i e compounds (up o 16.81%). Al hough 70%
e hanol also showed high yields, 50% e hanol was conside ed he mos ene gy-e icien op ion. The
d y ex ac ob ained was a yellow, hyg oscopic powde wi h a cha ac e is ic odo , and i s pa icle size
anged be ween 0.16–0.37 mm. In e ms o g anulo me ic composi ion, he −1000+500μm ac ion
p edomina ed (33.29%). Flowabili y was measu ed a 2.89·10⁻³ kg/s, he angle o epose was 55.49°,
and esidual mois u e con en was 4.2%.
Conclusions: he s udy demons a ed ha ul asonic ex ac ion o Cu cuma longa is an
e ec i e and ene gy-sa ing me hod o ob aining d y ex ac . The use o 50% e hanol as a sol en
was ound o be he mos op imal, ensu ing maximum yield o bioac i e compounds. The p oposed
echnology enables he p oduc ion o high-quali y d y ex ac , which can be p ac ically applied in he
pha maceu ical indus y o he de elopmen o hepa op o ec i e, an ioxidan , and o he bioac i e
p epa a ions. In he u u e, he ob ained ex ac can se e as a p omising basis o he c ea ion o new
dosage o ms in pha maceu ical manu ac u ing.
