Targeting of HIF2-driven cachexia in kidney cancer
Abstract
The processed dataset for the OSRC-2 and 786-O cell secretome experiment and the data tables from Figure 2. The processed dataset for Figure 3. Sex-stratified analysis of Belzutifan and NKT2152 clinical data in RCC patients (source data for Fig. 6 and Extended Data Fig. 8. Uncropped western blot scans
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Fig. 1e Cyclin D1 NDRG1 HIF2a Vincluin
Streptavaidin-HRP (Fig. 2b) Streptavaidin-HRP (Fig. 2a) IGFBP3 (Fig. 2b) MMP2 (Fig. 2b) MMP2 (Fig. 2a) IGFBP3 (Fig. 2a) Fig. 2a,b
Cyclin D1 NDRG1 HIF2a Vincluin Extended Data Fig. 1g
HIF2a HIF1a NDRG1 β-Actin Extended Data Fig. 3e Extended Data Fig. 3i HIF1a HIF2a NDRG1 β-Actin
Extended Data Fig. 4d Cyclin D1 NDRG1 HIF2a Vincluin Cyclin D1 NDRG1 HIF2a Vincluin V5-tag Extended Data Fig. 4e b-Actin NDRG1 HIF2a Extended Data Fig. 4g V5-tag
Extended Data Fig. 5a Cyclin D1 NDRG1 HIF2a Vincluin V5-tag Extended Data Fig. 5d V5-tag NDRG1 b-Actin
Cyclin D1 NDRG1 HIF2a Vincluin Extended Data Fig. 6h