Documenting the chemistry of Life, why and how?

Documenting the chemistry of Life, why and how? Pierre-Marie Allard - COMMONS Lab https://doi.org/10.5281/zenodo.17310143! Slide contents licensed under!CC-BY-SA 4.0 Feel free to share and/or modify. To heal ourselvesTo understand Nature 200 years of natural products research < 1% of plant metabolites have been characterized Centuries required to fully document plant metabolites -Physical isolation of a compound can requires monthes of work! -Strong publication bias (new or bioactives only are reported) ~ 350'000 compounds ~ 30'000 species 200 years of natural products research < 1% of plant metabolites have been characterized ~ 350'000 compounds ~ 30'000 species 1 sample - 10 min > 100 samples / day 1 sample 10 min 10'000 spectra 500 annotations Yes ... but ! 1. LCMS data sucks m/z signal intensity RT m/z RT signal intensity RT RTRT RT RT signal intensity signal intensity signal intensity signal intensity signal intensity signal intensity signal intensity signal intensity signal intensity signal intensity signal intensity RT RT https://www.worldwildlife.org/publications/living-planet-report-2020! METABOLOME EARTH INITIATIVE Profile the metabolic content of all currently known species on Earth. A massive undertaking ... METABOLOME EARTH INITIATIVE ... with three objectives •Explore and understand the chemical foundations of the biosphere •Benefit human society •Protect biodiversity Project 1 Project III Project 1 Project IV Project III Project 1 Project n Project IV Project III Project 1 Project n Project IV Project III Project 1 Project II Project n Project IV Project III Project 1 Project II User community Researchers, policy makers, industry, national parks, curators, public etc. HO O OH OH OH Project n Project IV Project III Project 1 METABOLOME EARTH KNOWLEDGE BASE BUILDING KNOWLEDGE Accessing chemodiversity Knowledge acquisition Knowledge dissemination Project II Knowledge organisation User community Researchers, policy makers, industry, national parks, curators, public etc. HO O OH OH OH Project n Project IV Project III Project 1 METABOLOME EARTH KNOWLEDGE BASE BUILDING KNOWLEDGE Accessing chemodiversity Knowledge acquisition Knowledge dissemination Advance life sciences Project II Knowledge organisation User community Researchers, policy makers, industry, national parks, curators, public etc. HO O OH OH OH Project n Project IV Project III Project 1 METABOLOME EARTH KNOWLEDGE BASE BUILDING KNOWLEDGE Accessing chemodiversity Benefit human society Knowledge acquisition Knowledge dissemination Advance life sciences Project II Knowledge organisation User community Researchers, policy makers, industry, national parks, curators, public etc. HO O OH OH OH Project n Project IV Project III Project 1 METABOLOME EARTH KNOWLEDGE BASE BUILDING KNOWLEDGE Accessing chemodiversity Protect biodiversity Benefit human society Knowledge acquisition Knowledge dissemination Advance life sciences Project II Knowledge organisation User community Researchers, policy makers, industry, national parks, curators, public etc. HO O OH OH OH Project n Project IV Project III Project 1 METABOLOME EARTH KNOWLEDGE BASE BUILDING KNOWLEDGE MAKING IMPACT Accessing chemodiversity Protect biodiversity Benefit human society Knowledge acquisition Knowledge dissemination Advance life sciences Project II Knowledge organisation METABOLOME EARTH INITIATIVE Wild ecosystems Botanical gardens Laboratory plants Diversity (species) Sampling (easiness of) Functions (understanding of) Diversity (species) Sampling (easiness of) Functions (understanding of) Diversity (species) Sampling (easiness of) Functions (understanding of) Conditions (control of environmental) Conditions (control of environmental) Conditions (control of environmental) Wild ecosystems Botanical gardens Laboratory plants Diversity (species) Sampling (easiness of) Functions (understanding of) Diversity (species) Sampling (easiness of) Functions (understanding of) Diversity (species) Sampling (easiness of) Functions (understanding of) Conditions (control of environmental) Conditions (control of environmental) Conditions (control of environmental) Wild ecosystems Botanical gardens Laboratory plants Diversity (species) Sampling (easiness of) Functions (understanding of) Diversity (species) Sampling (easiness of) Functions (understanding of) Diversity (species) Sampling (easiness of) Functions (understanding of) Conditions (control of environmental) Conditions (control of environmental) Conditions (control of environmental) "This number would be equivalent to generating 1!billion UUIDs per second for about 86!years." 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