DEVELOPMENT OF A TRANSDERMAL MEDICINE FOR WOUND HEALING

156 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz DEVELOPMENT OF A TRANSDERMAL MEDICINE FOR WOUND HEALING Nikitin K.A. Zhilyakova E.T. Belgorod State National Research University, Belgorod, Russian Federation e-mail: [email protected], phone +79087895220 https://doi.org/10.5281/zenodo.17328605 Relevance: the relevance is due to the high prevalence of wound pathology and the lack of complex and effective means for its treatment in the domestic pharmaceutical market. Purpose of the study: development of a transdermal dosage form of wound healing action Materials and methods: analytical research methods and computer modeling methods were used in the work Results: in order to reduce the development time and material costs, 8 compositions containing benzyl dimethyl[3-(myristoyl amino) as an antimicrobial component were selected using the Syntelly artificial intelligence platform for organic and medical chemistry.propyl]ammonium (miramistin), xymedon, or acecsamic acid as a reparant, as well as 1 of 5 NSAIDs: ketoprofen, ketorolac, benzydamine, nimesulide, or phenylbutazone, which are predicted to be stable. Three design options for a transdermal system have been proposed to provide controlled prolonged release. (pict.1). Picture 1. Schemes of proposed designs of transdermal therapeutic systems with woundhealing effect: matrix (A), reservoir (B), and combined (C). Conclusions: possible compositions and designs of a transdermal therapeutic system have been developed and theoretically substantiated. А 1 - Подложка Б 1 - Подложка 2 – Адгезив с растворенным ЛВ 2 - Резервуар с растворенным ЛВ 3 – Защитная пленка 3 - Мембрана 4 - Адгезив 5 - Защитная пленка В 1 - Подложка 2 - Резервуар с растворенным ЛВ 3 - Мембрана 4 - Адгезив с растворенным ЛВ 5 - Защитная пленка