DEVELOPMENT OF TECHNOLOGY FOR THE BIOLOGICAL ACTIVE ADDITIVE "DEPRESSFAN" WITH A CALMING EFFECT

164 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz DEVELOPMENT OF TECHNOLOGY FOR THE BIOLOGICAL ACTIVE ADDITIVE "DEPRESSFAN" WITH A CALMING EFFECT Shermatova Kh.B. Umarova F.A. Tashkent Pharmaceutical Institute, Tashkent, Republic of Uzbekistan [email protected] https://doi.org/10.5281/zenodo.17328700 Relevance: Biologically active supplements (BAS) are the most effective way to eliminate vitamin and mineral deficiencies, provided that the supplements contain biological substances in doses that meet the physiological needs of the human body. The State Policy Concept of the Republic of Uzbekistan on Healthy Nutrition stipulates that expanding the use of dietary supplements to improve the nutritional structure is an urgent measure. In addition, the concept implies the creation of new, scientifically substantiated formulations of dietary supplements. It is known that sedatives include medications and dietary supplements that have a general calming effect on the nervous system by reducing excitation processes. In addition, sedatives are used in combination with other medications in the early stages of treatment for various diseases. Research objective: Based on this, the aim of this work was to develop a technology for a calming dietary supplement called Depressphan, which is a tablet made from a mixture of dry extracts. Materials and methods: Ready-made dry extracts approved for medical use were used in the development: motherwort (FSP-221759413142-2022), St. John's wort (GF RUz III-volume, 1-part, pp.14-143), rhizome with valerian roots (FSP-221759413142-2022), Regel's zopnik (certificate compliance), Ginkgo biloba leaves (VFS 42-Uz-5462-2024). Excipients: potato starch, lactose 80M, Intracel MCC, sodium hydrocarbonate, Aerosil A-380, maltodextrin, calcium stearate, magnesium stearate. As a binding agent: purified water, 3-5-7% starch paste, and various types of ethyl alcohol. The finished dry extracts are fine-grained powders with a specific odor. Results: At the first stage of tablet development, 5 dry extracts were weighed with an accurate weight and sieved through a 1000 μm sieve, and then each extract was combined. The composition of the mixture of dry extracts was called "Depressfan". Next, 5 different formulations were obtained under standard conditions. The results of the experiment showed that it is advisable to use a 5% starch paste as a binding agent when preparing tablets using the wet granulation method. Next, to obtain model compositions of "Depressfan" tablets, an exact amount of a composition of dry extracts and auxiliary substances was weighed according to the corresponding formulations. All the components were thoroughly mixed and passed through a 160-micron sieve, and a 5% starch paste was added in three stages and thoroughly mixed. The wet mass was passed through a sieve with a hole of 1000 μm and spread in a layer of 1-1. 5 cm on the shelves of a drying cabinet. 55-60°C was dried to an optimal humidity of 5.0%. The resulting granulate was then powdered with magnesium stearate. The resulting tablet mass was tabletized using a Retsch PP 25 manual hydraulic tablet press with an 8 mm press tool. The quality of model tablets obtained from prepared masses was evaluated, and their technological properties were studied using the methods described in the literature. Conclusions: As a result of the research, an optimal technology for obtaining Depressfan 0.5 g in the form of tablets using the wet granulation method has been developed. The quality assessment of the tablets was carried out in accordance with the State Pharmacopoeia of the Republic of Uzbekistan, Volume I. The obtained tablets containing Intracel microcrystalline cellulose, starch, and 165 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz magnesium stearate as auxiliary substances fully meet the requirements of the State Pharmacopoeia of the Republic of Uzbekistan.