DETERMINATION OF THE CRYSTAL STRUCTURE OF THE SUBSTANCE "VIAREN"

301 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz DETERMINATION OF THE CRYSTAL STRUCTURE OF THE SUBSTANCE "VIAREN" Khujimov A.Kh. Olimov N.K. Usubbaeva Sh.M. Tashkent Pharmaceutical Institute, Tashkent city, Republic of Uzbekistan e-mail: [email protected] https://doi.org/10.5281/zenodo.17335209 Relevance: In pharmaceutical technology, most substances used in the development of solid dosage forms have a powdery nature. During the technological processing of such active substances, their physicochemical and technological properties are taken into account. According to biopharmaceutical theory, the quality indicators and bioavailability of finished dosage forms largely depend on the physicochemical and technological parameters of the medicinal substances, primarily on the crystalline modifications of the particles. From the literature data, it is known that the shape and size of the particles of the medicinal substance are one of the main factors that largely determine their technological properties and the technological properties of the masses of dosage forms. This, in turn, plays an important role in determining the type and quantity of excipients added to solid dosage forms, as well as the appropriate technology. The object of the research work: Tashkent Pharmaceutical Institute and Uz. In scientific cooperation with scientists of the Institute of Bioorganic Chemistry named after O. Sadykov, a mixture of the active substance "Viaren," which stimulates the immune system and increases male hormones, has been developed. The main goal of the research is to determine the crystalline structure of the particles of the active substance "Viaren.". Methods and techniques: Our experiments consisted of determining the crystalline form of particles of the active substance "Viaren," conducting crystallographic work in microscopic studies. The determination of the crystalline structure of the substance "Viaren" was carried out on an electron microscope of the Japanese model "Olympus SZX10" (126-fold magnification, ring, with a diode lamp illuminator) by simultaneous viewing and photographing with an eyepiece 2×10×6.3 and objective 50. Results: The results of the experiment on determining the crystalline structure of the active substance "Viaren," which stimulates the immune system and increases male hormone, are presented in the figure below. As can be seen from the results presented in the figure, the active substance "Viaren" was obtained by Prof. According to the crystallographic classification of E.E. Borzunov, it was established that it belongs to the group of platy, flaky, flaky, loose, and difficult-to-compact lowporous substances. Figure 1. Conclusions: Thus, for the first time, the crystalline structure of the particles of the mixture of active substances "Viaren," which stimulate the immune system and have a male hormone- 302 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz stimulating effect, was determined using an electron microscope. The obtained experimental results showed that the active substance "Viaren" was obtained by Prof. According to the crystallographic classification of E.E. Borzunov, it was established that it belongs to the group of plates, flakes, flakes, loose, difficult-to-compact, low-porous powdered substances. This, in turn, determines that when developing solid dosage forms from active substances with such a crystalline structure, it is necessary to select the type and quantity of scientifically based excipients in order to improve their technological properties.