INFLUENCE OF FACTORS ON THE ADSORPTION ACTIVITY OF SORBENTS

420 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz INFLUENCE OF FACTORS ON THE ADSORPTION ACTIVITY OF SORBENTS Osinovskaya K.V. Malakhova A.Yu. Arseniev N.A. Saint Petersburg State University of Chemistry and Pharmacy, Saint Petersburg, Russian Federation e-mail: [email protected] , tel. (+7812)499-39-00 to.4080 https://doi.org/10.5281/zenodo.17341382 Relevance: In case of drug poisoning, one of the first remedies is the introduction of enterosorbents into the human body. Studies show that enterosorbents may have different ability to bind toxins. Therefore, it was necessary to study the influence of factors such as the pH of the medium, temperature and time on the adsorption activity. The purpose of the study: to study the influence of certain factors on the change in adsorption activity over time Materials and methods. The following objects were used for the study: paracetamol substance, Activated Carbon tablets (RENEWAL, Russia), Activated Carbon substance, prototype SKT-6 AB. The following equipment was used during the work: SF-2000 spectrophotometer; C-MAG HS 7-IKA magnetic stirrer; Sartorius Secura 224-10RU analytical scales. A method for determining the adsorption activity of activated carbon using the example of paracetamol. For the mode, a magnetic stirrer: about 0.30-0.35 g (exact weight) of powdered tablets or a test sample was placed in a 100.0 ml flask and an aliquot of 25.0 ml of a freshly prepared 1% aqueous (or acidic) paracetamol solution was added. Stirred for 15 (30, 60, 90 and 120) minutes at t =20+2℃ and at t=37+2℃. Then the coal was filtered out and an aliquot of 1.0 ml was taken from the filtrate into a measuring flask, after which the volume of the measuring flask was adjusted to 100.0 ml with water (or 0.1 n hydrochloric acid) (solution A). An aliquot of 1.0 ml of solution A was taken and the volume of solution B was adjusted to 100.0 ml with water (or 0.1 n hydrochloric acid) in a measuring flask. An aliquot of 1.0 ml was taken from solution B and the volume of the solution in water (or 0.1 n hydrochloric acid) was adjusted to 50.0 ml in a measuring flask. After that, the optical density of solution B was measured. The results and their discussion. At the beginning, the effect of the pH of the medium on the adsorption activity of tablets of activated carbon of the RENEWAL brand and a prototype of activated carbon SKT-6AV was compared. According to the obtained data on adsorption activity, it was found that aqueous solutions of paracetamol are 5 times better sorbed than acidic ones. When the temperature rises to t=37+2 ° C, it was found that the adsorption activity of sorbents increases in an acidic environment compared to an aqueous one, for example, in tablets of activated carbon of the RENEWAL brand it increases by 1.5 times, and in a prototype of activated carbon SKT-6AV by 4.5 times. Conclusions. As a result of the conducted research and processing of the results, it can be said that the study of the adsorption activity of sorbets should be carried out in solution. hydrochloric acid 0.1 n at t = 37 + 2 ° C, since these conditions are as close as possible to the conditions of sorption of substances in the stomach. The adsorption activity of the SKT-6AV activated carbon prototype turned out to be higher than that of RENEWAL brand activated carbon tablets.