THE THERAPEUTIC EFFECTIVENESS IN EXPERIMENTAL GASTRIC ULCERS ACID SODIUM SALT WITH SALLITSILAT INDUKSION GLITSERRIZIN ANALYSIS OF MONOAMMONIY

459 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz THE THERAPEUTIC EFFECTIVENESS IN EXPERIMENTAL GASTRIC ULCERS ACID SODIUM SALT WITH SALLITSILAT INDUKSION GLITSERRIZIN ANALYSIS OF MONOAMMONIY T. B. Mustanov Alfraganus University, Tashkent city, Republic of Uzbekistan e-mail: [email protected] https://doi.org/10.5281/zenodo.17342341 Current period, gastric and o‘n two fingers of the intestine wounds (peptic ulcer disease) health storage system important clinical and social problems one as distinguished is. The world healthyliqni storage organization data according, this pathology of the population, 10-20 % up to that part of the cover will. Though modern in pharmacology wide ko‘lamli medicinal drugs available are, despite them each always also of the patient's individual needs for a complete answer you give can't. For this reason, natural source and less nojoiz‘ya effect have that substances, the therapeutic capabilities of a deep study topical is. The research purpose. Central Asian region o‘suvchi Glycyrrhiza glabra (licorice) from the plant separated and taken glitserrizin acid monoammoniy of salt (glycerol) sodium sallitsilat using generated was experimental gastric ulcers on anti the effects of evaluate. Material and methods. Experience white laboratory rats o‘out-check-in passengers, animals three into groups were divided. Each of a group of 10 rats from the composed toe‘become, in them l. m. romanov, v. l. zini a , and is koll v. e. by recommended was modifikatsiyalangan model on the basis of gastric ulcer was called. • 1-group – control (treatment failed), • 2-group – metiluratsil with treated (reference drug), • 3 and 4-groups – glycerol suitable on the basis of 50 mg/kg and 75 mg/kg, a dose ingested taken have. Treatment of 7 days during out did not go. The survey at the end of the animals surgical method is taken, the stomach is cut and opened , and mucous on the floor wound area planimetry method were assessed. Also, paul's index (healing effect) considered is. Results and discussion. Control group , all rats with gastric ulcers determine, in their o‘far central surface warp 13.9 mm2 to up was. Metiluratsil methodology‘llab was in the group, wound area 9,8 mm2 to reduced and wounded animals the number of only 15 % by is reduced. Paul the index of this group, 43 % to up was. Glycerin methodology‘llab was in the group while it was significantly the results recorded were. • 50 mg/kg dose: the wound is the area of 5,6 mm2, ulcerative animals , the number of 35 % by decreased, paul the index – 71 %. • 75 mg/kg dose: the wound is the area of only 1.8 mm2 to up reached, wounded animals the number of 50 % by shortrdi, paul the index while 90 % to be reached. Glycerol content in glitserrizin acid mucous layer of protection as important biologically active to be able to toe‘become, prostaglandin synthesis , stimulates, mucous production, production increases and antioxidant activity shows. These factors of wound process of the lights serve will. That is in addition to, glitseramning immunomodulyator properties of the body's total reactive that increases, this while not only symptomatic treatment, but also in pathogenesis either‘naltirib the complex therapy provides. Summary 460 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz 1. Glycerin, sodium sallitsilat using they cited experimental gastric ulcers in high therapeutic effect is possible that you will determine. 2. 75 mg/kg dosages glycerin, metiluratsil with in comparison to 3 times more effective is, the gastric ulcer depth and the size dramatically reduce. 3. This drug natural came out, relatively low toxicity and high efficiency, it is of clinical practice into the introduction to the opportunities it opens. 4. In the future glitseramning other wound in the model, results, and clinical research applied to order according.