Bioresorbable Na-ion Battery for Temporary Medical Devices

Department of Flexible Electronics INSPIRING INNOVATION SINCE 1816 Bioresorbable Na-ion Battery for Temporary Medical Devices Thierry Djenizian 09 April 2025 Department of Flexible Electronics 2 Microbatteries for wearable technologies S. Mukherjee, A. Albertengo, T. Djenizian, Energy Storage Mater., 42, 773 (2021) Department of Flexible Electronics 3 Microbatteries for wearable technologies Department of Flexible Electronics 4 Microbatteries for wearable technologies Example of a 2D battery system Department of Flexible Electronics 5 Microbatteries for wearable technologies Discharge Charge Reduction: A + Li+ + e- = Li+,AOxydation: C-,Li+ = C + Li+ + eOxydation: Li+,A- = A + Li+ + eReduction: C + Li+ + e- = C-,Li+ C + Li+,A- = A + C-,Li+ A + C-,Li+ = C + Li+,A- Department of Flexible Electronics 6 New concepts and designs Microbatteries for wearable technologies Na-ion bioresorbable battery Department of Flexible Electronics •Provide a targeted and personalized therapy during a determined clinical time •Therapy: localized drug release, electrical stimulation, biosensing,communication,… •The TMI should be entirely bioresorbable to avoid a second surgery or potential rejection Interest in temporary medical implants (TMI) Example of a bioresorbable pacemaker for temporary heart stimulation Drawback: continously powered by external chargers DBS for stroke recovery and nerve regeneration by electrode stimulation Drawback: powered by implanted permanent batteries Bioresorbable ba3ery Y. S. Choi, et al., Nat. Biotech., 39, pages 1228 (2021) Department of Flexible Electronics Ø Bioresorbable TMIs need efficient transient energy systems Rechargeable battery technologies including Li-ion batteries are using toxic elements that cannot be safely degraded by the body and must be then removed by surgery and recycled after use Ø A rechargeable wearable power source in which all constituents are non-toxic and able to be degraded by physiological fluids have not been achieved yet Propose a new technology able to penetrate the biomedical market and revolutionize the bioresorbable electronics The main challenges Our successful achievement: Design a high performance battery that is implantable, bioresorbable, wireless rechargeable with a controlled lifetime (from days to several months) A Na-ion bioresorbable and flexible electrochemical accumulator. Patent # EP23170468.5, 2023 Bioresorbable battery Department of Flexible Electronics Wireless charging of implanted ba9ery The main concept Bioresorbable battery Department of Flexible Electronics In vivo studies of bare batteries Bioresorbable battery V. Muniraj, B. L. Vijayan, H. Hammoud, R. Delattre, M.Ramuz, E. Djenizian, E. Vandini, D. Giuliani, T. Djenizian, Bioresorbable and Wireless Rechargeable Implanted Na-ion Battery for Temporary Medical Devices, Adv. Funct. Mater., 2417353 (2025). üBio-disintegration Department of Flexible Electronics üToxicity Bioresorbable battery V. Muniraj, B. L. Vijayan, H. Hammoud, R. Delattre, M.Ramuz, E. Djenizian, E. Vandini, D. Giuliani, T. Djenizian, Bioresorbable and Wireless Rechargeable Implanted Na-ion Battery for Temporary Medical Devices, Adv. Funct. Mater., 2417353 (2025). Ex vivo studies of bare batteries Department of Flexible Electronics Bioresorbable battery In vitro studies of PLGA-encapsulated batteries V. Muniraj, B. L. Vijayan, H. Hammoud, R. Delattre, M.Ramuz, E. Djenizian, E. Vandini, D. Giuliani, T. Djenizian, Bioresorbable and Wireless Rechargeable Implanted Na-ion Battery for Temporary Medical Devices, Adv. Funct. Mater., 2417353 (2025). Department of Flexible Electronics üElimination time is controlled by the PLGA thickness üDesign of a predefined bioresorbable batteries that may operate days or several weeks ✕The matter of carbon black… For aesthetical reason Bioresorbable battery In vivo studies of PLGA-encapsulated batteries V. Muniraj, B. L. Vijayan, H. Hammoud, R. Delattre, M.Ramuz, E. Djenizian, E. Vandini, D. Giuliani, T. Djenizian, Bioresorbable and Wireless Rechargeable Implanted Na-ion Battery for Temporary Medical Devices, Adv. Funct. Mater., 2417353 (2025). Department of Flexible Electronics Electrochemical performance of batteries implanted in artificial skin Bioresorbable battery Design of a predefined bio-eliminable battery that may operate days or several weeks V. Muniraj, B. L. Vijayan, H. Hammoud, R. Delattre, M.Ramuz, E. Djenizian, E. Vandini, D. Giuliani, T. Djenizian, Bioresorbable and Wireless Rechargeable Implanted Na-ion Battery for Temporary Medical Devices, Adv. Funct. Mater., 2417353 (2025). Department of Flexible Electronics Bioresorbable battery V. Muniraj, B. L. Vijayan, H. Hammoud, R. Delattre, M.Ramuz, E. Djenizian, E. Vandini, D. Giuliani, T. Djenizian, Bioresorbable and Wireless Rechargeable Implanted Na-ion Battery for Temporary Medical Devices, Adv. Funct. Mater., 2417353 (2025). Department of Flexible Electronics Wireless recharging Bioresorbable battery V. Muniraj, B. L. Vijayan, H. Hammoud, R. Delattre, M.Ramuz, E. Djenizian, E. Vandini, D. Giuliani, T. Djenizian, Bioresorbable and Wireless Rechargeable Implanted Na-ion Battery for Temporary Medical Devices, Adv. Funct. Mater., 2417353 (2025). Department of Flexible Electronics 23 The main issue Mg(OH)2 𝑀𝑔 +2𝐻20' ⟶ 𝑀𝑔 𝑂𝐻 2+ 𝐻2 Increase of the cell resistance due to the oxidation reactions induced by O2 from air and the moisture from the electrolyte Department of Flexible Electronics Bioresorbable battery Current collectors: Mg à Mo Anode: NTP-C, carbon black, Na-CMC Cathode: NMO, carbon black, Na-CMC Polymer electrolyte: Sodium sulfate, Na-CMC (less moisture) Department of Flexible Electronics 25 Last achievements