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This Zenodo deposit contains a publicly available description of the Dataset: "PD5D_MTG_MEGA_Chip_Genotype". Dataset Description: This dataset represents the PLINK bed format genotype data of PD5D subjects (PD5D_MTG_snRNAseq). All subjects were genotyped on the Infinium Multi-Ethnic Global-8 v1 chip. Raw genotypes were processed with PLINK (v1.90) and basic quality control, including removal of low quality genotypes and low-quality variants, was performed. Please note that the position information in the file was based on human GRC37/hg19 reference genome. Authors: • Scherzer, Clemens; ORCID:0000-0002-0567-9193 • Serrano, Geidy; ORCID:0000-0002-9527-2011 • Beach, Thomas; ORCID:0000-0003-3296-6128 • Liao, Zhixiang; ORCID:0000-0001-7014-5465 • Lin, Zechuan; ORCID:0000-0003-2270-5194 ASAP Team: Scherzer Dataset Name: scherzer-pmdbs-genetics, v1.0 Principal Investigator: Dr.Clemens Scherzer, [email protected] Dataset Submitter: Dr.Zechuan Lin, [email protected] Publication DOI: NA Grant IDs: ['ASAP-000301'] ASAP Lab: Scherzer, Dong, and Levin ASAP Project: Parkinson5D: deconstructing proximal disease mechanisms across cells, space, and progression Project Description: Here we will develop a molecular atlas of Parkinson's disease (PD) useful for mapping GWAS/familial genetics to proximal mechanisms in five dimensions: brain cells (1D), brain space (3D), and disease stage (1D). We will reveal how genetic variants modulate transcription in specific cells in specific topographic locations of midbrain and cortex during the progression of neuropathology from healthy brains to prodromal to symptomatic disease. This research will for the first time integrate whole genome sequencing, single-nucleus transcriptomics, and high-resolution spatial transcriptomics of 100 human brains with cell-specific mechanistic analyses in model systems. Submission Date: 2025-10-30 This dataset is made available to researchers via the ASAP CRN Cloud: cloud.parkinsonsroadmap.org. Instructions for how to request access can be found in the User Manual. This research was funded by the Aligning Science Across Parkinson's Collaborative Research Network (ASAP CRN), through the Michael J. Fox Foundation for Parkinson's Research (MJFF). This Zenodo deposit was created by the ASAP CRN Cloud staff on behalf of the dataset authors. It provides a citable reference for a CRN Cloud Dataset
