Single-nucleus transcriptomic analysis of the dorsal striatum from 6-month-old G2019S LRRK2 mutant mice

This Zenodo deposit contains a publicly available description of the Dataset: "Single-nucleus transcriptomic analysis of the dorsal striatum from 6-month-old G2019S LRRK2 mutant mice". Dataset Description: We performed single-nucleus transcriptomic analysis of the dorsal striatum from 5 wild-type and 5 G2019S LRRK2 mutant mice. This dataset contains the raw fastqs files (grouped together by indexes) from mouse dorsal striatum, sorted by 10 samples (S1 to S10), with files separated by read 1 (R1), read 2 (R2), index reads (I1 and I2), and which lane they were in on the S4 flow cell (L1 to L4). These files are created by bcl2fastq of Cell Ranger; the sequences in those files were used for the alignments. Authors: • Khan, Shahzad; ORCID:0000-0003-3962-0226; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307 • Lin, Yu-En; ORCID:0000-0002-5848-5405; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307 • Pfeffer, Suzanne; ORCID:0000-0002-6462-984X; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307 ASAP Team: Alessi Dataset Name: alessi-mouse-sc-rnaseq-dorsal-striatum-g2019s, v1.0 Principal Investigator: Suzanne Pfeffer, [email protected] Dataset Submitter: Yu-En Lin, [email protected] Publication DOI: 10.1073/pnas.2402206121 Grant IDs: ['ASAP-000463'] ASAP Lab: Pfeffer lab ASAP Project: Consequence of LRRK2 mutation in mouse dorsal striatum by single nucleus RNA sequencing Project Description: We employed single-nucleus RNA sequencing of the dorsal striatum from wild-type and G2019S LRRK2 mutant mice to elucidate the dysregulation of Hedgehog-related pathways in PD. Submission Date: 2025-09-18 This dataset is made available to researchers via the ASAP CRN Cloud: cloud.parkinsonsroadmap.org. Instructions for how to request access can be found in the User Manual. This research was funded by the Aligning Science Across Parkinson's Collaborative Research Network (ASAP CRN), through the Michael J. Fox Foundation for Parkinson's Research (MJFF). This Zenodo deposit was created by the ASAP CRN Cloud staff on behalf of the dataset authors. It provides a citable reference for a CRN Cloud Dataset