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CRC Metacohort

A.Bigas and L.Espinosa Lab

Abstract

This repository provides the processed metacohort created from different colon cancer datasets with following GEO series: GSE14333, GSE143985, GSE17536, GSE17537, GSE33114, GSE38832, GSE39582. The .RData file contains two data frames enclosing the following information: ‘pheno.data’ data frame includes patients phenotypic information. Rows refer to patients and columns to pheno variables. Disease free survival (DFS) time and event are available for all patients, but other variables might show missing values. ‘exprs.data’ data frame includes normalized and batch corrected microarray expression data. Rows refer to microarray probes and columns to patients except for the first three colums that indicate corresponding probe id, gene symbol and Jetset score. Source code for data generation can be found at the following github repository: https://github.com/BigaSpinosaLab/RESOURCES_CRC_metacohort_generation. In addition, a summary of the metacohort has been added.

Full text

2688 samples Discarded 1515 samples Not CRC Not enough information Different microarray platform 1118 samples ATM gene 208442_s_at 210858_x_at 212672_at 1570352_at Export CRC_metacohort_August_2025.RData 1118 samples Useful* samples Useful* - DFS_TIME + DFS_EVENT - No duplicates fRMA normalization + ComBat By Dataset CRC Metacohort Preparation Workflow CRC Metacohort Summary Before After CRC Metacohort Batch (dataset) Effect Removal