Porous titanium substrates coated with a bilayer of bioactive glasses
Abstract
Porous titanium substrates coated by dripping-sedimentation technique with a novel bilayer of (45S5 / 1393) bioactive glasses are proposed to overcome some limitations of the use of titanium for implants, such as the stress shielding and the poor osseointegration. Composition, thickness, roughness and micromechanical behavior (P-h curves) of the coating and the influence of the porous titanium substrates have been characterized. Best results were found for the substrate with 30 vol.% of porosity and a range size of 355 ‒ 500 μm, since it enhanced the mechanical and biofunctional behavior, due to the good adhesion of the 1393 bioglass to the substrate and the greater bioactivity of the 45S5 bioglass, which would be in contact with the bone.
Full text
Porous titanium substrates coated with a bilayer of bioactive glasses Ana M. Beltrána, Ana Alcudiab, Belén Beginesb, José A. Rodríguez-Ortiza, Yadir Torresa,* a Departamento de Ingeniería y Ciencia de los Materiales y el Transporte, Escuela Politécnica Superior, Universidad de Sevilla, Virgen de África 7, 41011 Seville, Spain b Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, 41012 Seville, Spain * Corresponding author: y[email protected] Figure 1: Scheme of a porous Ti substrate fabricated by space-holder technique, coated by the bilayer coating.
2 Figure 4: SEM images of the cross-section of the porous c.p. Ti substrates (a,c) and their corresponding confocal images (c,d). (a,b) 30 vol. %, 100 ‒ 200 μm and (c,d) 60 vol. % and 355 ‒ 500 μm. Figure 6. Loading-unloading curves (P-h curves) of coated (monolayer and bilayer) porous c.p. Ti substrates.
3 4. Conclusions In summary, the results obtained in this research work related to the manufacture and characterization of c.p. Ti substrates coated with a novel bilayer BG 1393 ‒ BG 45S5 allow confirming that the space-holder technique is a an effective technique to obtain porous substrates, with a content and pore size range guaranteeing not only the biomechanical (rigidity and mechanical resistance) but also the biofunctional (facilitate infiltration and adhesion of the coating) behavior. ..................................the titanium substrate and a greater bioactivity of the BG 45S5 with bone tissue. Acknowledgments This work was supported by the Junta de Andalucía–FEDER (Spain) through the Project Ref. US-1259771 and the project 2004/00001203 (RYC-2004-001497) from M.E.C. (Spain). The authors also thank student J.A. Guardiola for his contribution and laboratory technician J. Pinto for his support in microindentation tests. References [1] I.R. Dental Implants Market Size & Growth, Dental Implants Market Size, Share & Trends Analysis Report By Product (Titanium Implants, Zirconium Implants), By Region (North America, Europe, Asia Pacific, Latin America, MEA), And Segment Forecasts, 2018 - 2024, 2018. https://doi.org/10.18637/jss.v042.i08. [2] C. Palma-Carrió, L. Maestre-Ferrín, D. Peñarrocha-Oltra, M.A. Peñarrocha- Diago, M. Peñarrocha-Diago, Risk factors associated with early failure of dental implants. A literature review, Med. Oral Patol. Oral Cir. Bucal. 16 (2011) 2–5. https://doi.org/10.4317/medoral.16.e514.
4 [3] A. Solderer, A. Al-Jazrawi, P. Sahrmann, R. Jung, T. Attin, P.R. Schmidlin, Removal of failed dental implants revisited: Questions and answers, Clin. Exp. Dent. Res. 5 (2019) 712–724. https://doi.org/10.1002/cre2.234. [4] L. Bazli, H.N. Khoramabadi, A.M. Chahardehi, H. Arsad, B. Malekpouri, M.A. Jazi, N. Azizabadi, Journal of Composites and Compounds, 2 (2020) 18–25. [5] R. López-Píriz, B. Cabal, L. Goyos-Ball, A. Fernández, J.F. Bartolomé, J.S. Moya, R. Torrecillas, Current state-of-the-art and future perspectives of the three main modern implant-dentistry concerns: Aesthetic requirements, mechanical properties, and peri-implantitis prevention, J. Biomed. Mater. Res. Part A. 107 (2019) 1466–1475. https://doi.org/10.1002/jbm.a.36661. [20] X. Liu, M.N. Rahaman, Q. Fu, A.P. Tomsia, Porous and strong bioactive glass (13-93) scaffolds prepared by unidirectional freezing of camphene-based suspensions, Acta Biomater. 8 (2012) 415–423. https://doi.org/10.1016/j.actbio.2011.07.034. [21] F. Baino, S. Hamzehlou, S. Kargozar, Bioactive Glasses: Where Are We and Where Are We Going?, J. Funct. Biomater. 9 (2018) 25. https://doi.org/10.3390/jfb9010025. [22] D. Bellucci, V. Cannillo, A. Sola, Coefficient of thermal expansion of bioactive glasses: Available literature data and analytical equation estimates, Ceram. Int. 37 (2011) 2963–2972. https://doi.org/10.1016/j.ceramint.2011.05.048. [26] Y. Torres, S. Lascano, J. Bris, J. Pavón, J.A. Rodriguez, Development of porous titanium for biomedical applications: A comparison between loose sintering and space-holder techniques, Mater. Sci. Eng. C. 37 (2014) 148–155. https://doi.org/10.1016/j.msec.2013.11.036.
5 [27] S. Muñoz, J. Pavón, J.A. Rodríguez-Ortiz, A. Civantos, J.P. Allain, Y. Torres, On the influence of space holder in the development of porous titanium implants: Mechanical, computational and biological evaluation, Mater. Charact. 108 (2015) 68–78. https://doi.org/10.1016/j.matchar.2015.08.019. [28] S. Lascano, C. Arévalo, I. Montealegre-Melendez, S. Muñoz, J.A. Rodriguez- Ortiz, P. Trueba, Y. Torres, Porous titanium for biomedical applications: Evaluation of the conventional powder metallurgy frontier and space-holder technique, Appl. Sci. 9 (2019). https://doi.org/10.3390/app9050982. [29] Y. Torres, P. Trueba, J. Pavón, I. Montealegre, J.A. Rodríguez-Ortiz, Designing, processing and characterisation of titanium cylinders with graded porosity: An alternative to stress-shielding solutions, Mater. Des. 63 (2014) 316–324. https://doi.org/10.1016/j.matdes.2014.06.012. [32] H. Eckert, Structural characterization of bioactive glasses by solid state NMR, J. Sol-Gel Sci. Technol. 88 (2018) 263–295. https://doi.org/10.1007/s10971-018- 4795-7. View publication statsView publication stats