Dataset of Engineering Robust, Porous Guar Gum Hydrogels by One-Step Mild Synthesis: Impact of Porogen Choice on Rheology and Sustained Gastroretentive Amoxicillin Delivery

Página 1 de 8 Title: Engineering Robust, Porous Guar Gum Hydrogels by One-Step Mild Synthesis: Impact of Porogen Choice on Rheology and Sustained Gastroretentive Amoxicillin Delivery [Dataset]. Authors: Fátima Díaz-Carrasco; M.-Violante de-Paz*; Matea Katavić; Estefanía García-Pulido; Álvaro Santos-Medina; Lucía Muíña-Ramil; M. Gracia García-Martín; Elena Benito. * Correspondence: [email protected]. Affiliation: Departamento de Química Orgánica y Farmacéutica, Universidad de Sevilla, C/ Prof. García González, n.º 2, 41012-Sevilla, España. Researcher email ORCID Fátima Díaz-Carrasco [email protected] 0009-0001-5922-0548 M.-Violante de-Paz* [email protected] 0000-0002-6544-4732 Matea Katavić --- Estefanía García-Pulido [email protected] Álvaro Santos-Medina [email protected] Lucía Muíña-Ramil [email protected] M.-Gracia García-Martín [email protected] 0000-0002-7171-5236 Elena Benito [email protected] 0000-0002-8796-6873 Página 2 de 8 Content Title: .......................................................................................................................................... 1 Authors: ................................................................................................................................. 1 Affiliation: .............................................................................................................................. 1 Keywords: .............................................................................................................................. 3 Abbreviations: ........................................................................................................................... 3 Data of degradability of GG-systems. ......................................................................................... 4 AMOX release from single-step prepared and loaded formulations .............................................. 5 PEG used as porogen ............................................................................................................. 5 (pH 2.0) .............................................................................................................................. 5 (pH 5.0) .............................................................................................................................. 5 Sucrose used as porogen ....................................................................................................... 6 (pH 2.0) .............................................................................................................................. 6 (pH 5.0) .............................................................................................................................. 6 AMOX release from post-loaded IPN ........................................................................................... 7 PEG used as porogen ............................................................................................................. 7 (pH 2.0) .............................................................................................................................. 7 (pH 5.0) .............................................................................................................................. 7 Sucrose used as porogen ....................................................................................................... 8 (pH 2.0) .............................................................................................................................. 8 (pH 5.0) .............................................................................................................................. 8 Página 3 de 8 Keywords: Guar gum hydrogel; Interpenetrating polymer network ; (IPN); Diels-Alder crosslinking; one-pot synthesis; porosity modulation; PEG porogen; sucrose porogen; Gastroretentive drug delivery systems; GRDDS. Abbreviations: AMOX: amoxicillin; GG: guar gum; IPN: interpenetrating polymer network; PEG: porosogen polyethylene glycol-350; Suc: porosogen sucrose; t₅₀ (h): time (h) to 50% degradation of formulation mass. Página 4 de 8 Data of degradability of GG-systems. NAME and pH* KEY Degradability over time (h): percentage of IPN mass remaining t₅₀ (h)** 1 2 3 4 5 6 7 8 24 48 F1 (pH 2.0) GG-DA-AMOX25 82 72 66 61 56 46 38 33 11 0 5.02 F1 (pH 5.0) GG-DA-AMOX25 85 77 71 66 61 52 44 39 17 0 6.16 F2 (pH 2.0) GG-DA-AMOX40 79 67 60 54 49 39 31 26 7 0 3.94 F5 (pH 5.0) GG-DA-AMOX40 83 73 66 60 55 45 37 32 14 0 5.02 F3 (pH 2.0) GG-DA-PEG5-AMOX25 96 92 89 87 84 80 77 75 35 0 13.9 F3 (pH 5.0) GG-DA-PEG5-AMOX25 97 93 91 88 86 82 80 78 42 0 15.5 F4 (pH 2.0) GG-DA-PEG5-AMOX40 95 90 87 84 81 76 73 70 29 0 12.18 F4 (pH 5.0) GG-DA-PEG5-AMOX40 96 92 89 86 83 79 76 73 36 0 13.65 F5 (pH 2.0) GG-DA-PEG10-AMOX25 94 88 83 79 75 69 64 60 20 0 9.73 F5 (pH 5.0) GG-DA-PEG10-AMOX25 95 90 85 81 77 72 68 64 27 0 8.93 F6 (pH 2.0) GG-DA-PEG10-AMOX40 93 86 80 75 71 64 59 55 16 0 8.56 F6 (pH 5.0) GG-DA-PEG10-AMOX40 94 88 83 78 74 68 64 60 23 0 9.81 F7 (pH 2.0) GG-DA-PEG50-AMOX25 92 84 77 71 66 58 52 47 12 0 7.33 F7 (pH 5.0) GG-DA-PEG50-AMOX25 93 86 80 75 71 64 59 55 19 0 8.71 F8 (pH 2.0) GG-DA-PEG50-AMOX40 90 80 72 65 59 50 43 38 8 0 5.96 F8 (pH 5.0) GG-DA-PEG50-AMOX40 92 83 76 70 65 57 51 46 15 0 7.25 F9 (pH 2.0) GG-DA-Suc5-AMOX25 94 89 85 82 79 74 70 67 29 0 11.57 F9 (pH 5.0) GG-DA-Suc5-AMOX25 95 91 87 84 81 77 73 70 35 0 12.85 F10 (pH 2.0) GG-DA-Suc5-AMOX40 92 84 78 73 69 62 56 52 19 0 8.19 F10 (pH 5.0) GG-DA-Suc5-AMOX40 93 86 81 76 72 66 61 57 25 0 9.37 F11 (pH 2.0) GG-DA-Suc10-AMOX25 90 80 73 67 62 54 47 42 13 0 6.54 F11 (pH 5.0) GG-DA-Suc10-AMOX25 92 83 76 71 66 59 53 48 20 0 9.37 F12 (pH 2.0) GG-DA-Suc10-AMOX40 88 77 69 62 56 47 40 34 9 0 5.44 F12 (pH 5.0) GG-DA-Suc10-AMOX40 90 80 72 66 60 52 45 40 16 0 6.37 F13 (pH 2.0) GG-DA-Suc50-AMOX25 86 73 64 56 50 40 32 26 6 0 4.44 F13 (pH 5.0) GG-DA-Suc50-AMOX25 88 77 69 62 56 47 40 34 13 0 5.52 F14 (pH 2.0) GG-DA-Suc50-AMOX40 84 69 59 50 43 32 23 16 3 0 5.44 F14 (pH 5.0) GG-DA-Suc50-AMOX40 87 74 64 56 49 39 31 25 10 0 4.47 * pH at which the degradation study was conducted; ** Time (h) to 50% degradation of formulation mass Página 5 de 8 AMOX release from single-step prepared and loaded formulations PEG used as porogen (pH 2.0) AMOX release from single-step prepared and loaded formulation (PEG, pH 2.0) PEG5-AMOX25 PEG5-AMOX40 PEG10-AMOX25 PEG10-AMOX40 PEG50-AMOX25 PEG50-AMOX40 Time (h) F3 error F4 ERROR F5 error F6 ERROR f7 ERROR F8 ERROR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 44.27 2.39 60.88 3.04 20.79 2.27 55.72 2.79 17.34 0.15 13.49 0.70 2.00 54.21 1.94 80.97 1.62 27.78 0.08 67.89 1.36 22.17 2.60 16.75 0.41 3.00 78.83 13.32 85.95 4.30 29.95 1.69 70.06 3.50 22.24 1.14 17.62 0.50 5.00 71.59 0.47 94.44 0.94 31.00 0.75 77.19 0.77 23.62 0.07 18.91 0.71 8.00 82.41 1.45 100.00 2.00 36.56 1.95 78.59 1.57 26.48 1.67 19.63 0.71 (pH 5.0) AMOX release from single-step prepared and loaded formulation (PEG, pH 5.0) PEG5-AMOX25 PEG5-AMOX40 PEG10-AMOX25 PEG10-AMOX40 PEG50-AMOX25 PEG50-AMOX40 Time (h) F3 error F4 ERROR F5 error F6 ERROR f7 ERROR F8 ERROR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 42.82 8.11 60.54 3.03 19.30 1.61 27.46 1.37 32.17 4.65 12.00 2.09 2.00 51.36 3.72 77.20 3.09 22.44 0.66 38.34 1.53 18.46 0.75 13.31 0.32 3.00 57.99 2.21 78.73 3.94 25.88 0.15 47.37 2.37 19.78 0.67 15.28 0.43 5.00 94.57 3.95 88.24 2.65 27.88 0.15 55.57 1.67 21.31 0.51 16.75 0.31 8.00 78.64 6.98 89.99 4.50 30.60 0.10 62.54 3.13 24.12 0.95 18.64 0.35 Página 6 de 8 Sucrose used as porogen (pH 2.0) AMOX release from single-step prepared and loaded formulation (Suc, pH 2.0) Suc5-AMOX25 Suc5-AMOX40 Suc10-AMOX25 Suc10-AMOX40 Suc50-AMOX25 Suc50-AMOX40 Time (h) F9 error F10 ERROR F11 error F12 ERROR F13 ERROR F14 ERROR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 26.19 0.76 14.39 0.50 20.84 0.51 17.17 0.08 15.96 2.05 9.63 4.35 2.00 34.66 0.91 17.94 0.88 16.59 0.38 20.64 1.19 17.37 0.31 11.77 3.05 3.00 40.90 1.58 20.26 0.71 18.46 1.32 35.12 4.57 20.55 0.25 13.83 2.26 5.00 74.96 1.54 36.46 0.84 22.02 0.93 28.20 2.52 22.80 0.17 14.67 1.99 8.00 65.55 1.04 37.28 4.05 25.27 0.09 27.60 2.77 24.76 0.51 17.00 2.12 (pH 5.0) AMOX release from single-step prepared and loaded formulation (Suc, pH 5.0) Suc5-AMOX25 Suc5-AMOX40 Suc10-AMOX25 Suc10-AMOX40 Suc50-AMOX25 Suc50-AMOX40 Time (h) F9 error F10 ERROR F11 error F12 ERROR F13 ERROR F14 ERROR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 45.97 0.61 16.66 1.41 8.65 0.14 11.09 1.46 17.09 0.08 14.59 0.11 2.00 40.22 3.80 16.73 0.04 40.23 0.08 24.18 2.05 43.07 1.13 20.20 0.23 3.00 55.75 3.33 18.83 1.05 49.88 0.16 25.24 2.63 46.57 1.12 20.65 0.12 5.00 70.56 1.15 19.92 1.21 56.17 0.43 27.49 0.02 47.81 1.83 21.13 0.42 8.00 72.00 4.66 21.88 1.72 61.00 0.66 29.58 0.04 44.33 2.11 23.26 0.59 Página 7 de 8 AMOX release from post-loaded IPN PEG used as porogen (pH 2.0) AMOX release from post-loaded IPN (PEG, pH 2.0) PEG5-AMOX25 PEG5-AMOX40 PEG10-AMOX25 PEG10-AMOX40 PEG50-AMOX25 PEG50-AMOX40 Time (h) B3.4-AMOX25 error B3.4-AMOX40 ERROR B5.6-AMOX25 error B5.6-AMOX40 ERROR B7.8-AMOX25 ERROR B7.8-AMOX40 ERROR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 32.70 3.23 48.84 2.10 17.72 7.66 1.64 0.12 9.30 8.02 8.39 7.25 2.00 50.61 9.66 57.11 5.98 44.33 3.59 39.11 8.67 41.73 1.48 44.40 14.91 3.00 61.34 0.28 52.70 3.45 57.56 0.33 55.65 1.73 54.87 4.73 57.76 6.86 5.00 69.99 1.63 60.05 1.98 81.43 0.59 60.29 2.03 65.72 0.32 61.92 0.29 8.00 72.49 0.41 61.54 0.82 91.06 2.33 63.73 0.34 75.68 5.81 63.99 0.89 (pH 5.0) AMOX release from post-loaded IPN (PEG, pH 5.0) PEG5-AMOX25 PEG5-AMOX40 PEG10-AMOX25 PEG10-AMOX40 PEG50-AMOX25 PEG50-AMOX40 Time (h) B3.4-AMOX25 error B3.4-AMOX40 ERROR B5.6-AMOX25 error B5.6-AMOX40 ERROR B7.8-AMOX25 ERROR B7.8-AMOX40 ERROR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 36.87 1.21 22.77 0.86 10.54 9.27 9.38 6.62 0.86 0.23 1.07 0.07 2.00 53.54 10.91 41.76 2.42 34.89 10.86 32.51 8.79 17.12 2.08 17.46 3.93 3.00 64.59 1.30 45.12 4.76 48.24 9.58 43.92 1.47 34.41 3.85 35.78 3.89 5.00 69.39 0.90 58.10 3.18 67.67 7.54 49.01 0.78 53.69 14.98 40.34 2.17 8.00 71.39 0.25 65.16 4.78 68.61 6.32 75.06 12.24 76.38 4.08 53.77 3.51 Página 8 de 8 Sucrose used as porogen (pH 2.0) AMOX release from post-loaded IPN (Suc, pH 2.0) Suc 5% Suc 10% Suc 50% B9.10-AMOX25 B9.10-AMOX40 B11.12-AMOX25 B11.12-AMOX40 B13.14-AMOX25 B13.14-AMOX40 t (h) AMOX 25% error 40% ERROR 25% error 40% ERROR 25% error 40% ERROR 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1 56.89 13.61 55.83 4.80 11.09 8.67 7.16 1.51 65.66 20.76 52.98 3.87 2 74.19 3.63 60.59 0.67 60.34 20.27 23.13 7.62 69.28 6.25 59.31 2.03 3 92.36 18.20 68.62 0.18 60.16 4.82 40.99 6.89 84.02 3.86 69.88 6.77 5 93.10 11.70 75.60 2.79 60.56 3.69 43.76 6.56 79.79 0.13 70.09 7.51 8 100.00 11.45 79.65 3.82 63.09 2.16 44.43 6.48 82.78 0.22 71.63 9.88 (pH 5.0) AMOX release from post-loaded IPN (Suc, pH 5.0) Suc 5% Suc 10% Suc 50% B9.10-AMOX25 B9.10-AMOX40 B11.12-AMOX25 B11.12-AMOX40 B13.14-AMOX25 B13.14-AMOX40 t (h) AMOX 25% error 40% ERROR 25% error 40% ERROR 25% error 40% ERROR 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1 59.43 15.26 51.46 5.45 11.90 1.23 14.24 2.25 55.43 20.61 7.25 0.33 2 78.96 1.14 61.12 6.69 32.25 2.27 31.19 8.62 70.63 7.32 53.73 3.21 3 86.62 2.79 67.64 7.18 56.32 10.26 39.69 10.51 78.75 3.05 63.98 4.73 5 96.00 2.19 72.10 5.97 61.82 5.74 42.97 10.46 83.61 0.49 71.23 6.04 8 100.1 9.57 72.29 2.86 62.00 6.73 44.22 8.63 83.36 0.30 70.57 2.39