Coordination Between Partial Robotic Exoskeletons and Human Gait: A Comprehensive Review on Control Strategies

Coordination Between Partial Robotic Exoskeletons and Human Gait: A Comprehensive Review on Control Strategies Julio S. Lora-Millan 1 , 2 , Juan C. Moreno 3 and E. Rocon 1 * 1 Centre for Automation and Robotics, Consejo Superior de Investigaciones Científicas-Universidad Politécnica de Madrid, CSICUPM, Madrid, Spain, 2 Electronic Technology Department, Universidad Rey Juan Carlos, Madrid, Spain, 3 Neural Rehabilitation Group, Cajal Institute, Spanish National Research Council (CSIC), Madrid, Spain Lower-limb robotic exoskeletons have become powerful tools to assist or rehabilitate the gait of subjects with impaired walking, even when they are designed to act only partially over the locomotor system, as in the case of unilateral or single-joint exoskeletons. These partial exoskeletons require a proper method to synchronize their assistive actions and ensure correct inter-joint coordination with the user’s gait. This review analyzes the state of the art of control strategies to coordinate the assistance provided by these partial devices with the actual gaitofthewearers.Wehaveanalyzedandclassified the different approaches independently of the hardware implementation, describing their basis and principles. We have also reviewed the experimental validations of these devices for impaired and unimpaired walking subjects to provide the reader with a clear view of their technology readiness level. Eventually, the current state of the art and necessary future steps in the field are summarized and discussed. Keywords: unilateral robotic exoskeleton, single-joint powered orthosis, gait assistance, coordination strategies, state-of-the-art 1 INTRODUCTION Robotic exoskeletons are wearable mechanisms capable of augmenting, restoring, or assisting the function of human limbs by acting in parallel (Pons, 2008). This technology can be applied in many fields, ranging from industrial (Fox et al., 2019) or military (Chu et al., 2006) domains, where the user is empowered to perform a heavy task, to space teleoperation (Lovasz et al., 2017) or health care (Cardona et al., 2020). More specifically, two of the fields in which lower-limb robotic exoskeletons have shown promising results are rehabilitation (Louie and Eng, 2016;Holanda et al., 2017)or assistance (Yan et al., 2015a) of human gait. In this context, significant research efforts have been made to develop and improve wearable robotic devices that provide proper assistance during gait. A considerable amount of works have addressed different aspects of the design, control strategies, and experimental validation of these devices. To understand and organize the large body of information on this topic, several authors have reviewed the development of lower-limb robotic exoskeletons from multiple perspectives [see (Sanchez-Villamañan et al., 2019) for a complete review of compliant actuators currently used in robotic exoskeletons or (Pinto-Fernandez et al., 2020) for a detailed analysis of performance metrics, for instance]. In terms of control strategies, Tucker et al. provided an overview of the different control strategies for lower-limb robotic prostheses and orthoses and introduced a three-level paradigm controller Edited by: Maura Casadio, University of Genoa, Italy Reviewed by: Camilla Pierella, University of Genoa, Italy Alejandro Melendez-Calderon, The University of Queensland, Australia *Correspondence: E. Rocon [email protected] Specialty section: This article was submitted to Bionics and Biomimetics, a section of the journal Frontiers in Bioengineering and Biotechnology Received: 23 December 2021 Accepted: 28 April 2022 Published: 25 May 2022 Citation: Lora-Millan JS, Moreno JC and Rocon E (2022) Coordination Between Partial Robotic Exoskeletons and Human Gait: A Comprehensive Review on Control Strategies. Front. Bioeng. Biotechnol. 10:842294. doi: 10.3389/fbioe.2022.842294 Frontiers in Bioengineering and Biotechnology | www.frontiersin.org May 2022 | Volume 10 | Article 8422941 REVIEW published: 25 May 2022 doi: 10.3389/fbioe.2022.842294 development (Tucker et al., 2015). This same paradigm was recently updated and completed by Baud et al., who systematically analyzed the control strategies of lower-limb exoskeletons by dividing them into functional units (Baud et al., 2021). Considering these three-level paradigms, Ma et al. performed a deeper review of the high-level controllers responsible for the voluntary control of robotic devices (Ma et al., 2019), while Miscon et al. focused on middle-level controllers, in particular, joint trajectory generation for robotic exoskeletons (Miskon and Yusof, 2014). Low-level controllers responsible for direct actuator control were reviewed by Meng et al. (2015). The review proposed by Yan et al. also focused on control strategies for lower-limb exoskeletons, more specifically, on strategies that assisted user’s gait (Yan et al., 2015a). Similarly, Li et al. also reviewed control strategies for lower-limb exoskeletons but centered on rehabilitation purposes (Li et al., 2021). Considering the number of actuated joints, robotic exoskeletons can be classified as single-joint or multi-joint (former, if they actuate over one unique joint; latter if more than one joint is assisted) (Yan et al., 2015a). Some authors have focused their reviews on single-joint exoskeleton robots. For instance, ankle robots have been reviewed by Mills et al. (2010) and also by Shi et al. (2019), while Chen et al. analyzed both knee (Chen et al., 2019) and hip (Chen et al., 2020) devices. In contrast with complete lower-limb exoskeletons, which act over the hips and knees (even ankles) of both limbs, partial exoskeletons act partially over the locomotor system of the wearer by exclusively assisting one joint (single-joint exoskeletons) or one leg of the user (unilateral exoskeletons). Although they present several advantages [they are simpler and lighter than bilateral devices (Baud et al., 2021) and can target the specific function of the assisted joint during gait (Yan et al., 2015a)], they need to ensure proper interjoint coordination, especially with non-actuated joints. Unlike complete exoskeletons, which can impose the appropriate coordination between joints and legs, partial exoskeletons cannot actuate globally in the entire locomotor system; therefore, this interjoint coordination needs to be resolved by the controller of the device. Such coordination requires a dual interaction with humans: cognitive and physical. Proper delivery of the assistance is required to ensure that the user can benefit from the exoskeleton’s assistance, but also, a predictable timing that matches the user’s pre-estimation is required to achieve the exoskeleton’s embodiment. This would lead wearers to assimilate the robot’s action; so the exoskeleton would not be used as a tool but as a part of the user’s body (Li et al., 2021). Understanding strategies that achieve proper coordination of human and robotic systems has become crucial, especially for those devices which aim to rehabilitate or assist the gait of impaired walking users. Although coordinated operation is crucial for the proper operation of a partial robotic exoskeleton, it has not yet been systematically analyzed in previous works. The main objective of this paper is to perform a comprehensive analysis of the different control strategies that are used to coordinate the action of partial exoskeletons with the user’s gait to ensure proper interjoint coordination. We have also included those strategies initially developed for bilateral or complete exoskeletons, that could be used to synchronize the action of partial exoskeletons. We have paid particular attention to the assessments and validations that the authors have carried out with their devices and strategies. The reported effects of each work on impaired or unimpaired walking subjects have also been summarized in this review. The content of this paper is organized as follows. Section 2 reports the literature search methodology that we followed. Section 3 describes the state of the art, organized into the five main coordination strategies that we identified. Finally, section 4 and section 5 discuss and conclude the main findings of this review. 2 LITERATURE SEARCH METHODOLOGY We conducted a literature search using two different databases: Scopus and Web of Science from January 2004 until December 2021. To obtain results that cover the coordination issue between humans and robots, especially in unilateral or single-joint devices, we used the following search query in the title, abstract, and keywords: Topic = {leg OR hip OR knee OR ankle OR foot OR [lower AND (limb* OR extremity OR body)]} AND Topic= (power* OR robot*) AND Topic = [ortho* OR exoskeleton* OR (wearable robot*) OR (portable robot*) OR (robot* suit) OR (robot exosuit)] AND Topic= (control* OR validation* AND Topic= (coord* OR unilateral OR (mono joint) OR (single joint) OR ((sound OR impaired OR paretic) AND (leg OR limb)) OR (hemip*)) Inclusion criteria for this review were as follows: 1) English full-text journal articles or conference proceedings. 2) Studies related to the design and control of a unilateral or single-joint robotic exoskeleton to assist gait. 3) Studies that involved a bilateral exoskeleton whose control strategy could be directly applied to the unilateral or singlejoint paradigms. 4) Studies with a description of the experimental validation and assistance results of the devices mentioned above. Exclusion Criteria Included 1) Documents that only described the mechanical structure of the device or the design of actuators or new materials intended for gait assistance. 2) Documents that described prosthesis or passive and uncontrolled orthosis. 3) Documents that lacked complete methods, results, or discussion sections. The initial number of articles (844) was reduced to 671 after looking for duplicated documents. After checking the title and abstract, we discarded 467 papers and 204 were selected for full-text reading. Based on the authors’ experience and the bibliography of the reviewed articles, 34 documents that were not included in the initial search were Frontiers in Bioengineering and Biotechnology | www.frontiersin.org May 2022 | Volume 10 | Article 8422942 Lora-Millan et al. Gait-Partial Exoskeleton Control Strategies also considered for full-text reading. Then, we selected the 161 documents that fulfilled the inclusion criteria to be reported in this review. Figure 1 shows the flow diagram of the literature search and the document selection procedure. 3 STATE OF THE ART Our analysis of the selected documents was focused on two main aspects: 1) coordination strategies with the actual user’s gait and 2) experimental validation of the devices regarding the subjects (number and pathology) and obtained results. The control strategies were analyzed regardless of the device’s morphology or actuation principle, based on the working principles that ensure proper interjoint coordination between the robotic exoskeleton and the user’s gait. The individual details of each reviewed paper are shown in Supplementary Table S1. Across the literature, we have identified five strategies to synchronize the action of wearable robotic devices with human gait. The most extended methodology exploits the cyclic nature of human gait by using a finite state machine. Some authors leverage this cyclic property to estimate the continuous gait phase, which is a function that increases monotonically from 0 to 100% between consecutive heel strikes, and use this variable for the timing of the robot assistance. Other methodologies are based on the activity generated by the user, relying on either the movement itself or the muscle activity. Finally, mathematical tools have been developed, as in the case of central pattern generators that simulate the full gait dynamics of a subject. Figure 2 shows a diagram of the proposed classification. 3.1 Coordination Based on Finite State Machine Since human gait is a continuous repetition of the same states and events, some authors have taken advantage of this cyclic nature to coordinate the action of robotic exoskeletons with human locomotion (Blaya and Herr, 2004;Kawamoto and Sankai, 2005;Zhang et al., 2017). Due to its simplicity, authors have used this strategy since the 1960s (Popovic et al., 1991,1995; Tomovic and McGhee, 1966). Figure 3 represents the conceptual description of this coordination strategy between robot and human gait. This coordination relies on detecting key events and consequent gait division into states. These key-events are related to the joint kinematics (maximum and minimum of the joint angle or the angular velocity) or events about the foot’s contact with the floor (heel-strike, flat-foot, toe-off, etc.,). A common method to follow the sequence of gait events is the use of a finite state machine (FSM) based on angular sensors (such as gyroscopes or potentiometers) (Di Natali et al., 2019;Xia et al., 2020) or pressure sensors (such as insole force resisting FIGURE 1 | Flow diagram of the literature search methodology for document selection. FIGURE 2 | Classification of the different kinds of human-robot coordination strategies identified throughout the systematic review. Frontiers in Bioengineering and Biotechnology | www.frontiersin.org May 2022 | Volume 10 | Article 8422943 Lora-Millan et al. Gait-Partial Exoskeleton Control Strategies sensors—FSR or foot switches) (Blaya and Herr, 2004;Kawamoto and Sankai, 2005;Shorter et al., 2011). Within this strategy, robot coordination can be achieved by different approaches. Some authors triggered a specific action when a key-event was detected (Kawamoto and Sankai, 2005; Zhang et al., 2017), while others changed the actuation mode of the robot depending on the current gait states determined by the FSM (Blaya and Herr, 2004). 3.1.1 Actuation Mode Depending on the Gait Subphase The contact of each foot with the floor can be used to divide the gait cycle of each leg into states, defining the stance and swing states for the contact and noncontact stages, respectively. Several authors tailored the actuation mode of their system according to the current gait state in different ways, modifying the impedance of the actuators (Blaya and Herr, 2004;dos Santos et al., 2017), their stiffness (Shamaei et al., 2013;2014a;2014b,2015) or the torque levels (Horst, 2009;Forrester et al., 2016). The most extended method was to modulate the impedance level of the robotic joint according to the biomechanical requirements of the human joint during each gait state. Typically, a high-impedance model was applied during stance to assist weight acceptance, while a low-impedance model allowed free movement of the leg during the swing state (Blaya and Herr, 2004;Chinimilli et al., 2020;dos Santos et al., 2017;Kim et al., 2015;Shamaei et al., 2013;Villa-Parra et al., 2017;El Zahraa Wehbi et al., 2017;Xu et al., 2019;Zhou et al., 2016). A different approach consisted of adjusting the torque assistant profile depending on the gait state derived from biomechanical models. Thus, ankle exoskeletons applied plantarflexion torque during weight loading to prevent foot drop, and applied plantarflexion torque during preswing and dorsiflexion torque during swing phase to prevent toe drag (Kim et al., 2011,2020;Roy et al., 2013;Forrester et al., 2016;Choi et al., 2018). Meanwhile, knee exoskeletons reinforced the extension of the joint during stance and guide the movement during the swing phase of the gait (Horst, 2009;Wong et al., 2012;Stein et al., 2014; Arazpour et al., 2016;Lee et al., 2020;Liu and Wang, 2020). In other cases, this state-dependent actuation mode was exploited by elastic actuators to store energy during the loading phase and release it afterwards to assist the movement of the joint. Thus, body inertia during the stance phase collaborated to compress an elastic actuator that was decompressed during the swing, releasing the elastic energy and assisting the movement of the leg (Ward et al., 2011;Di Natali et al., 2019). 3.1.2 Action Triggered by the Detection of Key-Events Some exoskeletons based the timing of their assistance on detecting certain key-events, typically the heel strike. When this event was detected, the device triggered the application of a predefined position and velocity (Kawamoto et al., 2009), torque (Shorter et al., 2011;Sridar et al., 2018,2020), or work profiles (Mooney et al., 2014a,2014b,2014c;Mooney and Herr, 2016). In addition to the heel strike, other foot events could also be used to trigger a different assistive profile, such as push-off (Acosta-Sojo and Stirling, 2022)orflat-foot events (Lerner et al., 2018). A set of different joint events can also be used to trigger different assistive profiles in different gait states (Gomez-Vargas et al., 2021;Lerner et al., 2017b,2017a;Xia et al., 2020;Yeung et al., 2017,2021). To improve the efficacy of the assistance, some authors scaled the duration of the reference profile to the duration of previous steps (Beyl et al., 2011;Knaepen et al., 2014;Jackson and Collins, 2015,2019;Lim et al., 2015;Witte et al., 2015;Galle et al., 2017; Steele et al., 2017;Zhang et al., 2017;Ma et al., 2018;Malcolm et al., 2018;Wei et al., 2019;Bacek et al., 2021). By doing so, the FIGURE 3 | Conceptual representation of the robot-gait coordination based on a finite state machine: each gait state or the transitions between them are associated to a different action in the exoskeleton. Frontiers in Bioengineering and Biotechnology | www.frontiersin.org May 2022 | Volume 10 | Article 8422944 Lora-Millan et al. Gait-Partial Exoskeleton Control Strategies assistive profile was adapted to different gait velocities and could be used independently of the individual gait features of the user. However, the trigger of these profiles was still limited to the event detection moment. 3.2 Coordination Based on the Real-Time Estimation of the Continuous Gait Phase For the coordination between wearable robots and human gait, several authors have opted to use the concept of continuous gait phase in their control paradigms (Ronsse et al., 2011;Giovacchini et al., 2015;Awad et al., 2017b;Jin et al., 2017). The gait phase is a continuous function that increases monotonically from 0 to 100% between consecutive heel strikes, so it provides continuous information of the timing inside the current step and can be used to synchronize the robot’s action with the current step timing. We have identified two main methods to estimate the gait phase in real-time: the first method is based on the duration of previous steps (Awad et al., 2017b;Jin et al., 2017;Ding et al., 2018), while the second method uses adaptive frequency oscillators (also called adaptive oscillators, AOs) to learn features of the gait as a cyclic process, including the gait phase (Ronsse et al., 2011;Giovacchini et al., 2015;Seo et al., 2016). Additionally, a third residual subgroup includes those methods that use kinematic information and machine learning or optimization techniques. In Figure 4, we depict a representation of a coordination strategy based on the gait phase estimated by an AO. 3.2.1 Step Time Based Gait Phase Estimation The core of this strategy consists of estimating the phase of the gait cycle considering the duration of the last step and the time lapse from the last heel strike. Therefore, it is a quite simple strategy to estimate the continuous gait phase while the step duration remained constant. Once the gait phase is known, it is used to determine the timing of the assistive actions of the robotic exoskeleton (Oymagil et al., 2007;Bae et al., 2015,2018a,2018b; Ding et al., 2016a,2016b,2017,2018;Lee et al., 2016,Lee et al., 2017 G.;Awad et al., 2017a,2017b;Jin et al., 2017;Young et al., 2017;Bougrinat et al., 2019;Huo et al., 2019;Kang et al., 2019; Kim et al., 2019;Siviy et al., 2020;Haufe et al., 2021). 3.2.2 Adaptive Frequency Oscillators To synchronize the action of a robotic exoskeleton with the human gait, several authors considered the periodic nature of gait-related signals (such as kinematics or muscular activity) and used its features (e.g., amplitude, frequency, or phase) for the control of the robot. AOs are mathematical tools that can be synchronized with a quasi-periodic signal by learning its features as variable states (Ronsse et al., 2013). Although this approach initially worked for quasi-sinusoidal signals, it was extended to non-sinusoidal periodic signals by coupling a pool of AOs to a kernel-based non-linear filter (Ronsse et al., 2011). Once converged, the amplitude, frequency, and phase of the AO corresponded to the amplitude, frequency, and phase of the input signal. If this input was a characteristic gait signal, its features could be used inside the control strategy of a robotic wearable device. The information provided by the AO could be used only for assistance timing, considering the phase and frequency of the gait (Lenzi et al., 2013;Aguirre-Ollinger, 2015;Yan et al., 2015b; Cempini et al., 2015;Giovacchini et al., 2015;Ruiz Garate et al., 2016;Seo et al., 2016;Parri et al., 2017;Ruiz Garate et al., 2017; Sanz-Morere et al., 2018;Aguirre-Ollinger et al., 2019;Ishmael et al., 2019;Aguirre-Ollinger and Yu, 2021;Talatian et al., 2021; Tricomi et al., 2021), or it could also be used to reconstruct the source signal to use it directly as a reference for the low-level FIGURE 4 | Conceptual representation of the robot-gait coordination based on the gait phase estimation performed by an Adaptive Frequency Oscillator: the AFO estimates the continuous gait phase and uses it to synchronize the application of an assistive profile. Frontiers in Bioengineering and Biotechnology | www.frontiersin.org May 2022 | Volume 10 | Article 8422945 Lora-Millan et al. Gait-Partial Exoskeleton Control Strategies controller (Zanotto et al., 2014)orasfiltered information to generate an assistive reference (Ronsse et al., 2011). Although the input of an AO was usually a kinematic signal, as reported in the mentioned articles, other signals could also be used. Measures from insole pressure sensors (Grazi et al., 2015; van Dijk et al., 2017), the linear envelope of muscular activity (Aguirre-Ollinger, 2013), or joint torques (Han et al., 2019) were also demonstrated to be reliable sources of information to estimate the gait phase with AOs. An extended approach, called Particularly Shaped Adaptive Oscillator (PSAO), was used to determine the gait phase and frequency from the hip angle (Seo et al., 2016;Lee H.-J. et al., 2017,Lee et al., 2017 S.-H.,2019). In addition, other information such as the user’s speed and the ground inclination was also estimated from the PSAO states and one inertial measurement unit (IMU) located at the user’s back. 3.2.3 Kinematics-Based Gait Phase Estimation These methods rely on the kinematic information of the joints to estimate the continuous real-time gait phase of the user. For example, the ANdROS prototype compared the movement of both knees and hips with reference trajectories and minimized the difference between them to estimate the current gait phase (Aoyagi et al., 2007;Unluhisarcikli et al., 2011). Other methods used machine learning techniques to learn the gait features from experimental data. In (Kang et al., 2020), the authors used a neural network model based on hip and thigh angles to estimate the gait phase in real-time. In contrast, in (Li et al., 2011;Zhang et al., 2021), the authors opted for learning a model to characterize the kinematics of the gait and then used a cross-correlation method (Li et al., 2011) or a particle swarm optimization (Zhang et al., 2021) to estimate the continuous gait phase. 3.3 Coordination Based on User Kinetics and Kinematics This section presents the coordination methodologies that relied on the users’movements. These techniques calculate the assistance according to the current movement of the limbs and can be divided according to the movements or restrictions that are considered: 1) residual movements of the assisted limb, 2) movements of the unassisted limb, or 3) coupling restriction between joint movements. Figure 5 represents an example of the working principle of these strategies. 3.3.1 Coordination Based on the Movement of the Assisted Limb Some authors calculated the assistive action of their robotic devices based on the residual movements of the leg that was aimed to be assisted. For example, in (Lai et al., 2013), the authors exploited the strong correlation between the knee angle and hip angular velocity during the swing phase of gait. Other sources of information were the pressure measurements between the thigh muscles and the exoskeleton straps (Wu et al., 2015) for generating a velocity reference profile, or the biological moment of the ankle for generating assistive (Fang and Lerner, 2021;Gasparri et al., 2019;Orekhov et al., 2020,2021) or resistive (Conner et al., 2020) torque profiles. 3.3.2 Coordination Based on the Movement of the Non-Assisted Limb The assistance provided by a unilateral exoskeleton can be based on the assumption that the movement of both legs is delayed 180°. This paradigm is called echo-control (Wang et al., 2013) and implies that the movement of one leg can be used to estimate the FIGURE 5 | Conceptual representation of the robot-gait coordination based on the kinematics of the gait: a flow control imposed restrictions between the movement of hip and knee to generate the assistive profile that is applied by the robot. Frontiers in Bioengineering and Biotechnology | www.frontiersin.org May 2022 | Volume 10 | Article 8422946 Lora-Millan et al. Gait-Partial Exoskeleton Control Strategies movement of the contralateral leg to apply an assistive strategy or directly replicate the gait pattern of the non-assisted leg (Nguyen et al., 2013;Kawamoto et al., 2014,2015;Zhang et al., 2016;Xie and Huang, 2019;Baser et al., 2020;Lora-Millan et al., 2020). The prototype developed by Peng et al. also based its movement on sound limb kinematics, but according to a leader-follower multiagent system framework (Peng et al., 2020). Instead of directly using the trajectory depicted by the unimpaired leg, some authors used regression models to estimate the desired position of the impaired limb according to the position of the unimpaired limb. The complementary limb motion estimation (CLME) strategy computed the paretic limb’s targeted joint positions based on the healthy one’s current position by using synergetic information by referencing unimpaired walking subjects (Vallery and Buss, 2006;Vallery et al., 2007,2009). This method was extended by Hassan et al., who included the movement of a walking aid (a cane) as an input of the PCA algorithm (Hassan et al., 2012,2018) to estimate a target trajectory for the hip and knee joints. Nunes et al. also extended the PCA approach, but to obtain the torque primitives that originated the movement and used them as references for their knee exoskeleton (Nunes et al., 2018). 3.3.3 Coordination Based on the Restriction Between the Movements of the Joints Some authors exploited the inter-joint restrictions to coordinate the assistance provided by a robotic exoskeleton. This is the case for the force-field control that imposed a force field around a healthy foot trajectory in the joint space, so that users could be forced to move the foot inside this trajectory (Banala et al., 2007,2009). The second version of this controller included a tangential force to the prescribed trajectory to assist the user in the movement (Winfree et al., 2011;Jin et al., 2015,2018;Srivastava et al., 2015; Hidayah et al., 2020). Although the path control reinforced the constraints between hips and knees in the joint space during the swing (Martinez et al., 2018), it also allowed the user to modify the step length, because the users were able to control the exoskeleton freely during the stance phase. This controller was expanded by adding a tangential force to the prescribed path to assist the movement across it. This new version was called flow control (Martinez et al., 2019). Although this controller was initially developed for bilateral exoskeletons, it was adapted to be used in a knee exoskeleton in a single-joint flow control paradigm (Martinez et al., 2020). Considering a complete biomechanical model also leads to restrictions on the joint configuration. This is the case for the controller that considered the virtual pivot point (VPP) as the point above the center of mass through which the ground reaction forces should pass to obtain a stable gait. This controller aimed to apply such joint torques to modify the directions of these forces and ensure a stable gait by guiding them through the VPP (Zhao et al., 2017;Sharbafiet al., 2018). 3.4 Coordination Based on Muscular Activity Limb movements are inevitably coordinated with the biosignals that recruit the muscles involved in movements. Because of this, some authors used these signals to control their robotic exoskeletons, as represented in Figure 6. Three different approaches have been found in the literature: 1) using muscular activity as a trigger to execute predefined trajectories in the exoskeleton (Kawamoto et al., 2010), 2) calculating the assistive torque proportionally to the muscular activity (the approach called myoelectric proportional control) (Gordon and Ferris, 2007;Nilsson et al., 2014) or 3) employing FIGURE 6 | Conceptual representation of the robot-gait coordination based on the EMG signals from the user: the controller generates an assistance whose timing and amplitude depend on the muscular activity. Frontiers in Bioengineering and Biotechnology | www.frontiersin.org May 2022 | Volume 10 | Article 8422947 Lora-Millan et al. Gait-Partial Exoskeleton Control Strategies neuromechanical models to calculate the joint torque from the activity of the muscles involved in the gait (Fleischer and Hommel, 2008). 3.4.1 Exoskeleton Actions Triggered by Muscular Activity Similar to detecting certain gait key-events, muscular activity can also be detected and used to trigger a variety of actions in a device. Typically, this controller detects when muscular activity is above a certain threshold to perform an assistive action, such as triggering a torque profile (Kawamoto et al., 2010) or some predefined movements (Nilsson et al., 2014;Watanabe et al., 2014,2020). 3.4.2 Proportional Myoelectric Control In contrast to the previous strategy, in which muscular activity is discretely evaluated through a comparison with a threshold, proportional myoelectric control uses information from voluntarily activated gait muscles to continuously assist limb movement. This controller generates an assistance profile that is proportional to the recruitment of these muscles (Nilsson et al., 2014;SczesnyKaiser et al., 2019;Tan et al., 2018;Watanabe et al., 2014, 2020). The muscles involved in this controller depends on the morphology of the robotic exoskeleton, while the above mentioned works use flexor/extensor muscles of the hip and knee to assist these joints, soleus and gastrocnemius activity can be used to command an ankle exoskeleton (Cain et al., 2007;Gordon and Ferris, 2007;Sawicki and Ferris, 2008;Kinnaird and Ferris, 2009;Kao et al., 2010;Koller et al., 2017). Although the myoelectric proportional control usually utilize a fixed gain to calculate the assistance profile, Koller et al. introduced an adaptive gain that is a function of muscular activity (Koller et al., 2015). This adaptive paradigm leads to a more efficient assistive strategy by allowing users to find the optimal gait. An extension of the myoelectric proportional control avoids the co-contraction of pneumatic artificial muscle actuators by inhibiting flexor actuators when the extensor muscle is recruited (Sawicki and Ferris, 2009). As an improvement of the proportional myoelectric control, the proportional myoelectric propulsion (PMP) controller adjusts not only the amplitude of the assistance but also its timing (Takahashi et al., 2015). The PMP controller generates a torque profile proportional to the muscular activation when the ground reaction force is directed anteriorly to assist the plantar flexion ankle in hemiparetic subjects. In the second version of this controller, exoskeleton assistance is also modulated by gait speed, as a higher gait speed needed higher assistance (McCain et al., 2019). 3.4.3 Neuromechanical Models for Joint Torque Estimation The muscular activation signal can also be used to estimate joint torque using neuromechanical models. For example, Fleischer et al. developed a biomechanical model to estimate knee torque based on EMG recordings from the knee flexor/extensor muscles and provided it through an exoskeleton to assist the gait (Fleischer and Hommel, 2008). In contrast, Durandau et al. exploited the synergies between muculo-tendom units, so they developed a user-specific neuromechanical model based on 12 units, although measurements of only 8 of them were used (Durandau et al., 2019). This model estimated the joint torque, and a fraction of it was provided to the users to assist the movement of their lower limbs. 3.5 Central Pattern Generators Following a biomimetic approach, some authors have opted to emulate the central pattern generators (CPGs) responsible for generating coordinated patterns of cyclic activity that play a crucial role in the locomotion of vertebrate and invertebrate animals (Ijspeert, 2008). By mathematically modeling these CPG neural networks, it is possible to obtain robust and rhythmic movement characteristics of bipedal locomotion (Mishra et al., 2013). If CPGs are synchronized with an FIGURE 7 | Conceptual representation of the robot-gait coordination based on the use of a CPG: it estimates cyclic signals coordinated with the user’s gait that is used to generate the assistive profile for the robot. Frontiers in Bioengineering and Biotechnology | www.frontiersin.org May 2022 | Volume 10 | Article 8422948 Lora-Millan et al. Gait-Partial Exoskeleton Control Strategies external signal, typically a kinematic signal, they can also be used to coordinate the assistance provided by a robotic exoskeleton (Figure 7). For example, Mishra et al. described an algorithm that used a CPG with the movement of the sound leg of a stroke survivor to determine the trajectory of a rehabilitation robot that would assist the movement of their paretic leg (Mishra et al., 2014). In contrast, the CPG proposed for the Curara prototype simulated the excitation and inhibition of neurons of the central nervous system. It used the interaction torque between the robot and the impaired limb to estimate the gait phase and generate an assistive reference trajectory from a predefined pattern (Tsukahara and Hashimoto, 2016;Mizukami et al., 2018). Other authors opted for synchronizing the CPG output with the detection of floor contact events (Dzeladini et al., 2016; Tamburella et al., 2020) or with the estimated knee torque from the knee flexor/extensor EMG (Gui et al., 2017). 3.6 Experimental Validation Across the reviewed literature, the inconsistency found in the experimental validation of the reviewed control strategies is remarkable. As reported in other reviews (Pinto-Fernandez et al., 2020;Baud et al., 2021), the lack of common validation protocols and metrics makes it extremely difficult to compare results from different devices and reliably assess the benefits of each control strategy. Regarding the reviewed works, we found two main issues that were divergent: 1) the subject population that tested the devices and 2) the evaluated outcomes. Both items are summarized in Supplementary Table S1 for each reviewed paper. 3.6.1 Subjects Involved in the Validation The validation tests reported in the reviewed literature can be divided into three types. The first concerns the technical feasibility of the proposed device and/or the control method. In this case, some papers presented results in which no subjects were involved in the evaluation. In other cases, the authors reported simulation results (Mishra et al., 2014;Sharbafiet al., 2018) or experimental results on the robot’s ability to follow a prescribed trajectory, reject disturbances, or generate assistive profiles in time (Aoyagi et al., 2007;Unluhisarcikli et al., 2011; Zhang et al., 2016). Similarly, people with unimpaired or impaired walking were involved in other works just because their data were needed for the control strategies to use as input. In these cases, the authors only evaluated the assistance generation and how it was provided, instead of the effects on the unimpaired walking participants (Fleischer and Hommel, 2008; Hassan et al., 2012;Shamaei et al., 2013;Giovacchini et al., 2015; Zhou et al., 2016;Gui et al., 2017) or impaired walking participants involved (Sanz-Morere et al., 2018;Huo et al., 2019;Baser et al., 2020). In contrast, other studies involved human subjects because they were focused on evaluating the real effects of the exoskeleton’s assistance. Some authors involved unimpaired walking subjects because they were the target users (Mooney et al., 2014b;Galle et al., 2017;Malcolm et al., 2018;Acosta-Sojo and Stirling, 2022), although sometimes they participated as an earlier validation before involving impaired walking subjects (Vallery et al., 2007;Winfree et al., 2011;Hassan et al., 2012; Dzeladini et al., 2016;Seo et al., 2016). Typically, after such an early validation stage, the effects of the devices were evaluated in actually impaired walking subjects (Srivastava et al., 2015;Lee H.- J. et al., 2017;Hassan et al., 2018;Tamburella et al., 2020). On other occasions, these subjects were directly involved in experimental validations to assess the effect of a robotic exoskeleton in this population without the need for previous validations (Bae et al., 2015;Lerner et al., 2017a;Tan et al., 2018). 3.6.2 Assessed Outcomes As mentioned above, some authors reported technical validation of their devices, in which they evaluated the robot’s ability to follow a prescribed trajectory, reject disturbances, or generate assistive profiles at the correct time (Fleischer and Hommel, 2008; Beyl et al., 2011;Hassan et al., 2012;Shamaei et al., 2013;Zhou et al., 2016). Most of the reviewed articles reported information about how assistance affected those subjects who wore the exoskeleton. These effects were measured in impaired and unimpaired walking subjects while the robotic devices were assisting their gait. Throughout the reviewed literature, the authors focused on three different aspects during these validations. Most of them assessed how assistance modified the kinematics of the gait to produce a more symmetric gait (Bae et al., 2015;Arazpour et al., 2016;Liu and Wang, 2020) or a pattern closer to natural gait (Kawamoto et al., 2009;Winfree et al., 2011;Srivastava et al., 2015;Martinez et al., 2020;Gomez-Vargas et al., 2021) reduce drop-foot (Blaya and Herr, 2004;Yeung et al., 2017) or crouch gait (Lerner et al., 2017a), improve step length and height (Hidayah et al., 2020), or increase gait speed (Ruiz Garate et al., 2017;Mizukami et al., 2018). Other authors went beyond and evaluated the physiological effects of the provided gait assistance. Several authors detected changes in the lower limbs’muscular activity due to the robot’s action, pointing out that the subjects adapted their natural patterns according to the provided assistance (Gordon and Ferris, 2007;Steele et al., 2017;Tan et al., 2018). Similarly, some authors found reductions in the metabolic cost of transport, indicating that robotic assistance led to more efficient gait patterns with lower energetic cost (Koller et al., 2015;Lee H.-J. et al., 2017;Ding et al., 2018). 4 DISCUSSION In this paper, we have reviewed and classified the main control strategies that aim to synchronize the action of partial robotic exoskeletons with the current gait of their users. The distribution of the analyzed literature is represented in Figure 8. We have grouped the articles in this review according to their coordination strategies. The FSM-based coordination strategy was the most frequent, appearing in 34.8% of the reported articles due to its simplicity and favorable results. 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Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Copyright © 2022 Lora-Millan, Moreno and Rocon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Frontiers in Bioengineering and Biotechnology | www.frontiersin.org May 2022 | Volume 10 | Article 84229420 Lora-Millan et al. Gait-Partial Exoskeleton Control Strategies