Associations of women’s empowerment with neonatal, infant and under-5 mortality in low- and /middle-income countries : meta-analysis of individual participant data from 59 countries

1 DokuDT, etal. BMJ Global Health 2020;5:e001558. doi:10.1136/bmjgh-2019-001558 Associations of women’s empowerment with neonatal, infant and under-5 mortality in lowand /middleincome countries: metaanalysis of individual participant data from 59 countries David T Doku,1,2 Zulfiqar A Bhutta,3,4 Subas Neupane2 Original research To cite: DokuDT, BhuttaZA, NeupaneS. Associations of women’s empowerment with neonatal, infant and under-5 mortality in lowand /middleincome countries: metaanalysis of individual participant data from 59 countries. BMJ Global Health 2020;5:e001558. doi:10.1136/ bmjgh-2019-001558 Handling editor Dr Sanni Yaya ►Additional material is published online only. To view please visit the journal online (http:// dx. doi. org/ 10. 1136/ bmjgh2019001558). Received 11 March 2019 Revised 25 June 2019 Accepted 29 June 2019 For numbered affiliations see end of article. Correspondence to Dr David T Doku, Department of Population and Health, University of Cape Coast, Cape Coast, Ghana; dokudavid@ gmail. com © Author(s) (or their employer(s)) 2020. Reuse permitted under CC BYNC. No commercial reuse. See rights and permissions. Published by BMJ. AbsTrACT background Child survival and women’s empowerment are global public health concerns and important sustainable development goals (SDGs). Lowand middleincome countries (LMICs) have the largest burden of both phenomena. The aim of this study is to investigate a measure of women’s empowerment at individual and population levels and its potential associations with neonatal, infant and under-5 mortality at national and regional levels in 59 LMICs. Methods We used pooled populationbased crosssectional surveys from 59 LMICs (n=6 12 529) conducted from 2000 to 2015 using standardised protocols. We constructed individuallevel women’s empowerment index (ILWEI) and populationlevel women’s empowerment index (PLWEI) for LMICs and investigated the potential associations of these measures with neonatal, infant and under-5 mortality using twostage randomeffect individual participant data (IPD) metaanalysis. results The pooled neonatal mortality rate was 24 per 1000 live births. Infant and under-5 mortality rates were 43 and 55/1000 live births, respectively. In the pooled sample, 61.6% and 19.9% of women had autonomy regarding their healthcare and household decisionmaking, respectively, whereas 56.0% rejected domestic violence against women for any reason. IPD metaanalysis showed that children of women with low ILWEI had a higher risk of neonatal (OR: 1.18, 95% CI 1.14 to 1.22), infant (OR: 1.12, 95% CI 1.08 to 1.17) and under-5 (OR: 1.12, 95% CI 1.07 to 1.18) mortality compared with children of high ILWEI. Similar relationships were found across most of the regions as well as between PLWEI and all the three outcomes. Conclusions Women’s empowerment at individual and population levels is associated with neonatal, infant and under-5 mortality in LMICs. Our study underscores the importance of women’s empowerment in accelerating progress towards the attainment of the SDG targets for child survival in LMICs. Multisectoral and concerted efforts are necessary to eliminate preventable child mortality in these countries. InTroduCTIon The burden of neonatal, infant and under-5 mortality in lowand middleincome countries (LMICs) remains high despite significant progress in recent decades, especially the Millennium Development Goal (MDG) 4 target of twothirds reduction in the under-5 mortality between 1990 and 2015.1–9 Only 24 out of the 139 LMICs met the MDG 4.4–6 Under-5 mortality ratio is 1 in 147 in Key messages What is already known? ►Women’s empowerment is a key global developmental goal (Sustainable Development Goal 5 (SDG 5)) as well as a means to advance the other SDGs, including those related to neonatal, infant and under-5 survival (SDG 3). However, there is no standard or consistent measure for women’s empowerment across low/middleincome countries (LMICs) and diverse contexts. What are the new findings? ►Women’s empowerment was relatively low in LMICs. ►Children of women with low empowerment at both individual and population levels had a higher risk of neonatal, infant and under-5 mortality. Individual participant data metaanalysis shows evidence of associations of individuallevel women’s empowerment index with neonatal, infant and under-5 mortality in most countries and in every region in LMICs. ►Our findings suggest that women’s empowerment is critical to achieving SDG 3, which aims at reducing neonatal mortality to 12 deaths per 1000 live births and under-5 mortality to 25 death per 1000 live births by 2030. What do the new findings imply? ►Healthcare systems in LMICs should be structured to reach less empowered women’s children with lifesaving interventions. ►Our findings further underscore the need for multisectoral and concerted efforts to eliminate preventable child mortality in LMICs as well as making progress towards achieving the SDGs. on April 1, 2020 by guest. Protected by copyright.http://gh.bmj.com/BMJ Glob Health: first published as 10.1136/bmjgh-2019-001558 on 9 January 2020. Downloaded from 2 DokuDT, etal. BMJ Global Health 2020;5:e001558. doi:10.1136/bmjgh-2019-001558 BMJ Global Health highincome countries, whereas in subSaharan Africa and Southern Asia, the ratio is 1 in 12 and 1 in 19, respectively. The Sustainable Development Goal (SDG) 3, which aims at reducing neonatal mortality to 12 deaths per 1000 live births and under-5 mortality to 25 deaths per 1000 live births by 2030 is a global commitment to tackle the unfinished work of the MDG 4.10 Efforts to address child mortality have rightly focused on tackling immediate causes such as intrapartumrelated events, pneumonia, sepsis and diarrhoea.8 However, relatively distal factors, such as gender equality and women’s empowerment that fuel the immediate causes, have received little attention.11 Women’s empowerment is conceptualised as the process of enabling women with less influence or power to be able to make informed choices in all matters that affect their health and wellbeing. Empowerment entails two important constructs: the ability to formulate one’s own choices and act on them (agency) and the means through which one’s choices are exercised (resources).12–14 Gender equality and women’s empowerment are important components of the global developmental agenda. Efforts towards MDG 3, which sought to promote gender equality and women’s empowerment, did lead to some significant gains over the last two decades.4 However, girls and women still face many social, economic and cultural barriers, which hinder their own perception of their roles as well as the ability to achieve them.15 16 Given the importance of gender equality and women’s empowerment for social, economic and sustainable development, a separate goal, SDG 5 now underscores the global commitment towards addressing these issues.10 The SDGs are considered as an indivisible whole. Therefore, such a gap has important implications for their overall attainment.10 17 Women with low agency and resources may be limited in their ability to make choices regarding their own health and those of their children. Consequently, these circumstances can contribute to their own ill health and risk of mortality as well as that of their children.16 18 In two recent systematic reviews, one found an inverse association of women’s empowerment with child undernutrition in South Asia19 and the other a positive association of women’s empowerment with completion of childhood immunisation in LMICs.20 Likewise, lack of women’s empowerment and participation in community healthcare programmes were implicated in the failure of some countries to achieve the MDGs 4 and 5 targets for reduction in maternal and child mortality.21 JamesHawkins et al in their systematic review of the relationship between women’s agency and current contraceptive use in LMICs found a positive association.22 Although both child survival and women’s empowerment are of global importance, our systematic review of the literature suggests that no study has used metaanalysis of individual participant data (IPD) to explicitly investigate the effect of women’s empowerment on child survival outcomes in LMICs, the countries with the highest burden of both phenomena.4–6 21 Earlier researchers have used a number of context and regionspecific indices of women’s empowerment. For instance, Ewerling et al23 constructed Surveybased Women's emPowERment index (SWPER) as a tool for the assessment of women’s empowerment in subSaharan Africa. SWPER was developed for subSaharan Africa and its applicability to other regions, notably Latin America and the Caribbean has been questioned. Akseer et al24 also used different indicators as measures of empowerment for women in the Islamic world. These various indicators underscore the multidimensional nature of the construct of women’s empowerment. We used unique individuallevel data, which were collected using standardised demographic and health surveys (DHSs) and populationlevel data to investigate the effect of women’s empowerment on neonatal, infant and under-5 mortality in 59 LMICs. We also aimed to investigate the regional differences in these associations. MeTHods data We used nationally representative crosssectional data from 59 LMICs collected in DHSs using standardised questionnaires and protocols in order to facilitate international comparison. The DHSs have generated highquality data on important demographic, economic, social and health for LMICs and have been used in highquality research. The DHS data were collected at about 5year intervals across LMICs. DHSs collect data by interviewing women of reproductive age (15–49 years), their children and their households. DHSs are available to investigators through the World Wide Web (http://www. dhsprogram. com). Briefly, DHSs used a stratified twostage random sampling approach, consisting of a selection of census enumeration areas based on a probability, followed by a random selection of household from a complete listing of a household within the selected enumeration areas. In all the 59 countries, DHSs followed the same standard procedures. Further descriptions of DHS sampling procedures, validation of questionnaires and data collection methods are published elsewhere (http://www. dhsprogram. com). In this study, we used data collected on the outcome of the most recent live birth within 5 years preceding the survey for each woman of reproductive age 15–49 years. We used the most recent publicly available datasets conducted between 2000 and 2015 to generate a large dataset with sufficient statistical power to investigate the effect of women’s empowerment on neonatal, infant and under-5 mortality. Our study data represent 42% of the 139 LMICs globally. We restricted our analyses to the most recent singleton live birth for each woman of reproductive age (n=612 529). The countries were divided into three income groups according to the World Bank list of economies (24 lowincome countries, 24 lowermiddleincome countries and 11 uppermiddleincome countries)25 and their regional classifications according to the WHO (subSaharan, East Asia and Pacific, Europe and on April 1, 2020 by guest. Protected by copyright.http://gh.bmj.com/BMJ Glob Health: first published as 10.1136/bmjgh-2019-001558 on 9 January 2020. Downloaded from DokuDT, etal. BMJ Global Health 2020;5:e001558. doi:10.1136/bmjgh-2019-001558 3 BMJ Global Health Central Asia, Latin America and Caribbean, Middle East and North Africa, and South Asia) (table 1). ethical clearance Ethical clearance for the respective surveys was granted in the respective countries and permission to analyse the data was obtained from the DHS programme ( www. dhsprogram. com). Patient Involvement statement Patients were not involved in the design and implementation of this research. outcome measurements The outcome measures were neonatal, infant and under-5 mortality. Under-5 mortality was defined as the death of a liveborn baby within 5 years of life. Infant mortality was defined as the death of liveborn baby within 12 months of life and neonatal death refers to the death of a liveborn baby within the first 28 days of life. These were estimated based on information on the date of birth, date of death and the survival status, which were collected at the time of the survey through interviews. Age at death was recorded in days if the child died within 28 days of birth, otherwise in months. Measures of women’s empowerment In this study, we used indicators, which are applicable across a wide range of LMICs and which reflect the multidimensionality of the concept of empowerment to construct women’s empowerment indices. We developed two indices, individuallevel women’s empowerment index (ILWEI) and populationlevel women’s empowerment index (PLWEI) to measure women’s empowerment. The ILWEI was measured using three major indicators of women’s autonomy variables, namely autonomy in healthcare decision making, household decision making (making large household purchases, visits to family or relatives and how to spend money), and justification of domestic violence against women (if she goes out without telling her husband, neglects the children, argues with her husband or if she refuses to have sex with her husband) and three social independence variables, namely women’s education, frequency of reading newspaper and respondents who worked during past 12 months (online supplementary table S1). We constructed the ILWEI based on women’s responses to the three measures of autonomy and other three variables on social independence and categorised the scores into terciles as follows: low, medium and high. Furthermore, we constructed PLWEI based on three populationlevel indicators, namely the proportion of the female population with at least secondary education, the proportion of females’ share of parliamentary seats and the female labour force participation rates and categorised this into terciles as low, medium and high. These indicators were adapted from the United Nations Development Programme’s measure of the ratio of female to male human development index.26 Background characteristics of the mother (age, wealth quintile, parity and partner’s education) were also included in the analysis as covariates consistent with the previous study.9 The wealth quintile is the composite measure of the household’s cumulative living standard based on ownership of specified assets categorised into quintiles: poorest, poorer, middle, richer and richest. Body mass index (BMI) was calculated based on the height and weight of women, which were measured during the survey. BMI is used as a continuous variable in the analysis. BMI was calculated based on the height and weight measurement of women and used as a continuous variable. statistical analysis Data editing and imputation of missing procedures were conducted by the DHS Programme before data were released for use.27 The DHSs in LMICs are prone to incomplete, partial or inconsistent reporting of response for different questions because of its complex questionnaires. The purpose of data editing and imputation in the DHSs is to accurately reflect the population studied and make it useable for analysis.27 We further conducted data auditing and validation for each country using the countries’ survey protocols. Population sample weights were applied to the pooled data (table 1). Under-5 mortality per 1000 live births and the proportion of women who had no ILWEI in each country are presented in the world map (figure 1A,B). We conducted a principal component analysis (PCA) to construct ILWEI and PLWEI separately at individual and population levels, respectively, on a pooled dataset (online supplementary tables S2 and S3). We ranked the countries according to the level of women’s empowerment based on the PCA scores of ILWEI and PLWEI. We used twostage randomeffects IPD metaanalysis. First, we used multivariable logistic regression analysis to estimate ORs and their 95% CIs to investigate the association of neonatal, infant and under-5 mortality with ILWEI for each country and region, adjusting for the sociodemographic factors. We also adjusted the models for the effect of the multistage cluster sampling. Second, we conducted a metaanalysis of those ORs from the logistic regression analysis to investigate the effect of women’s empowerment on neonatal, infant and under-5 mortality for each country and region using randomeffects metaanalysis tools in Stata. The estimates for dummy women’s empowerment index variable (low and medium combined as low vs high) were analysed and plotted for each country and region. The true effect of the independent variable in each country is randomly distributed between countries with variance τ2. The estimate of the betweencountry variance τ2 modifies the weights used to calculate the pooled estimate. A random effect is given by: OR R= k ∑ i=1 wiORi k ∑ i=1 wi . Where wi =1 vi+τ 2 and the heterogeneity is estimated by formula Q =∑n i=1 {( 1 var ) x ( individual effect − pooled effect )2} . on April 1, 2020 by guest. Protected by copyright.http://gh.bmj.com/BMJ Glob Health: first published as 10.1136/bmjgh-2019-001558 on 9 January 2020. Downloaded from 4 DokuDT, etal. BMJ Global Health 2020;5:e001558. doi:10.1136/bmjgh-2019-001558 BMJ Global Health Table 1 Distribution of women’s empowerment measures by countries and regions Year of survey Total sample Women’s autonomy, % Healthcare Household decision making Domestic violence 0 1 2 3 No 1–3 4–5 Lowincome SubSaharan Africa Benin 2011–2012 12 545 61.0 19.6 18.2 29.7 32.5 82.5 12.0 5.6 Burkina Faso 2010 14 776 21.2 31.5 40.3 21.3 6.8 53.4 31.4 15.2 Burundi 2010 7798 76.8 17.3 27.6 48.6 6.5 25.5 47.8 26.7 Chad 2014–2015 18 074 24.2 34.0 29.6 22.2 14.2 22.1 35.9 41.9 Comoros 2012 3105 41.9 38.7 20.0 31.4 9.9 58.4 28.3 13.4 Congo D Rep. 2013–2014 17 692 45.6 23.7 21.7 28.5 26.0 23.2 44.8 32.0 Ethiopia 2011 11 597 72.0 13.5 22.3 45.9 18.3 22.1 34.7 43.2 Guinea 2012 6757 31.6 29.1 26.5 27.8 16.7 5.9 26.4 67.7 Liberia 2013 6256 76.8 8.7 15.5 49.4 26.5 54.7 32.9 12.4 Madagascar 2008–2009 12 449 88.6 3.0 9.5 45.6 41.8 68.2 27.1 4.7 Malawi 2010 18 850 53.4 28.5 38.8 23.7 9.0 87.5 9.5 3.0 Mali 2012–2013 10 069 13.5 56.0 27.5 11.6 4.9 21.4 39.8 38.8 Mozambique 2011 11 265 66.5 20.3 26.0 43.8 9.9 76.8 20.2 3.0 Niger 2012 12 882 20.5 45.7 31.5 18.7 4.1 37.7 22.6 39.7 Rwanda 2014–2015 7762 83.0 8.4 14.3 35.3 42.0 58.9 28.9 12.2 Senegal 2014 11 014 27.9 42.5 27.3 20.7 9.5 34.9 28.8 36.3 Sierra Leone 2013 11 691 52.5 29.9 16.3 39.7 14.2 29.8 41.7 28.6 Tanzania 2010 7939 57.2 39.7 24.2 24.5 11.6 41.5 32.6 25.8 Togo 2013–2014 6376 39.2 15.1 27.6 30.3 27.0 66.3 23.6 10.1 Uganda 2011 7813 58.5 20.9 23.8 33.0 22.4 40.2 43.7 16.0 Zimbabwe 2010–2011 5444 83.4 5.4 10.0 56.0 28.7 57.5 35.0 7.5 Latin America and Caribbean Haiti 2012 6703 71.0 5.9 13.6 36.6 43.9 82.1 15.4 2.6 South Asia Nepal 2011 5321 58.2 39.3 16.9 34.2 9.7 99.1 0.6 0.3 Pooled 234 178 49.5 26.5 24.9 30.9 17.8 48.5 29.1 22.4 Lowermiddleincome SubSaharan Africa Cameroon 2011 11 251 33.4 21.5 29.3 29.0 20.1 49.9 36.9 13.2 Congo 2011–2012 7842 38.1 12.5 25.7 34.6 27.2 38.1 61.9 0 Cote D'Ivoire 2011–2012 7141 31.4 31.2 29.4 21.4 18.1 48.0 33.3 18.7 Ghana 2014 5403 75.5 5.8 13.9 33.1 47.1 68.0 21.9 10.1 Kenya 2014 18 951 75.5 13.8 19.1 38.3 28.8 53.0 35.3 11.7 Lesotho 2014 3029 89.4 6.1 20.0 48.4 25.5 64.1 29.8 6.2 Nigeria 2013 30 726 35.2 26.9 32.7 17.4 23.0 61.0 22.4 16.5 Sao Tome 2008–2009 1756 67.6 15.5 20.3 38.7 25.5 80.1 16.8 3.1 Swaziland 2006–2007 2755 68.1 21.0 27.9 35.0 16.1 77.2 20.5 2.3 Zambia 2013–2014 12 970 72.3 15.7 23.8 41.0 19.5 47.5 27.6 24.9 EastAsia and Pacific Cambodia 2014 7113 91.4 1.3 3.8 31.8 63.1 48.0 41.7 10.4 Indonesia 2012 16 679 84.7 7.5 11.3 52.6 28.5 63.9 33.0 3.2 Philippines 2013 6886 95.9 2.3 12.5 51.6 33.7 85.3 13.6 1.0 Continued on April 1, 2020 by guest. Protected by copyright.http://gh.bmj.com/BMJ Glob Health: first published as 10.1136/bmjgh-2019-001558 on 9 January 2020. Downloaded from DokuDT, etal. BMJ Global Health 2020;5:e001558. doi:10.1136/bmjgh-2019-001558 5 BMJ Global Health Year of survey Total sample Women’s autonomy, % Healthcare Household decision making Domestic violence 0 1 2 3 No 1–3 4–5 TimorLeste 2009–2010 9653 87.3 3.2 14.7 77.2 5.0 10.6 53.2 36.2 Europe and Central Asia Armenia 2010 1431 91.7 9.4 17.4 60.5 12.7 89.3 10.4 0.3 Moldova 2005 1567 98.2 1.3 4.2 57.4 37.4 77.9 19.1 3.0 Ukraine 2007 1150 97.5 1.7 5.6 33.4 59.2 96.5 3.5 0 Latin America and Caribbean Bolivia 2008 8614 88.9 3.8 11.9 45.3 39.0 83.0 15.0 2.0 Honduras 2011–2012 10 015 83.1 6.4 18.8 45.9 28.9 85.7 11.5 2.8 Nicaragua 2001 32 093 86.8 12.3 18.2 38.9 30.7 82.4 14.0 3.7 Middle East and North Africa Egypt 2014 15 039 81.4 20.0 19.8 52.4 7.7 63.5 27.8 8.7 Morocco 2003–2004 30 915 59.0 31.4 14.5 45.1 9.0 27.1 28.8 44.1 South Asia Bangladesh 2014 7977 63.7 28.5 17.0 41.2 13.3 71.6 24.1 4.3 India 2005–2006 55 541 58.4 34.4 22.6 33.9 9.1 51.4 34.4 14.3 Pakistan 2012–2013 11 736 57.5 31.6 19.7 36.1 12.7 55.5 19.6 24.9 Pooled 318 231 66.3 20.8 20.0 39.0 20.3 57.1 28.0 14.8 Uppermiddleincome SubSaharan Africa Gabon 2012 4908 53.1 11.9 23.6 41.8 22.7 44.8 45.4 9.9 Namibia 2013 4658 86.7 6.6 13.3 47.8 32.3 67.5 25.1 7.4 Europe and Central Asia Albania 2008–2009 1545 80.2 22.2 21.2 46.1 10.5 63.5 29.4 7.1 Azerbaijan 2006 2254 58.8 39.5 25.9 29.7 4.9 40.6 41.9 17.5 Kyrgyz Republic 2012 3994 88.0 12.8 10.0 59.5 17.7 56.5 34.7 8.7 Latin America and Caribbean Colombia 2010 15 587 88.9 8.4 17.1 34.0 40.5 97.2 2.5 0.2 Dominican Rep 2013 3536 88.8 4.4 10.3 45.1 40.2 97.1 2.6 0.3 Guyana 2009 1853 91.4 6.4 6.0 65.8 21.8 82.9 13.6 3.5 Peru 2012 8629 83.1 7.0 16.2 48.2 28.6 96.4 3.3 0.3 Middle East and North Africa Jordan 2012 9475 89.4 9.5 19.8 59.4 11.3 75.4 23.4 1.2 South Asia Maldives 2009 3681 79.1 2.7 25.7 50.3 21.4 70.5 22.9 6.6 Table 1 Continued Where var = {( upper CI−lower CI ) 2xz }2 . The associations of PLWEI with neonatal, infant and under-5 mortality by regions (low income, lowermiddleincome and uppermiddleincome) were presented in scatter plots. For the scatter plots continuous scores of PLWEI were used. We also conducted a sensitivity analysis of the associations of our ILWEI with neonatal, infant and under-5 mortality in comparison with SWPER24 (online supplementary table S5, online supplementary figures S1–S3). All statistical analyses were conducted using STATA/SE V.14.0. resulTs The distribution of women’s empowermentrelated measures by income levels of the countries and the regions are presented in table 1. In the pooled sample, 61.6% of women had autonomy in decision making regarding their healthcare, 19.9% had autonomy in all the three indicators of household decision making and 56.0% on April 1, 2020 by guest. Protected by copyright.http://gh.bmj.com/BMJ Glob Health: first published as 10.1136/bmjgh-2019-001558 on 9 January 2020. Downloaded from 6 DokuDT, etal. BMJ Global Health 2020;5:e001558. doi:10.1136/bmjgh-2019-001558 BMJ Global Health Figure 1 World MAP showing the (A) proportion of under-5 mortality per 1000 live births and (B) proportion of women without empowerment in all three indicators (autonomy in healthcare decision making, household decision making and rejecting domestic violence against women for any reason). rejected domestic violence against women for any reason. Countryspecific under-5 mortality ranged from 11 per 1000 live births in Moldova to 98 per 1000 live births in Senegal (figure 1A). The proportion of women without empowerment in all three indicators varies from 0 in Armenia and Colombia to 22.98% in Guinea (figure 1B). The level of women’s empowerment varies across countries (online supplementary table S4). By ILWEI, Ukraine (1.64), Armenia (1.51) and Moldova (1.51) had the highest empowerment scores, whereas Guinea (−1.19), Mali (−0.90) and Burkina Faso (−0.89) had the lowest scores. The level of empowerment by PLWEI ranges from the lowest −1.79 (Niger) to highest 2.38 (Moldova). A metaanalysis of countrylevel associations of ILWEI with the child mortality outcomes, adjusted for the sociodemographic factors, are presented in figure 2A–C. This analysis shows minimal heterogeneity and suggests that in most countries, children of women with low empowerment were more likely to die as neonates, infants or before their fifth birthdays. The strongest association of women’s empowerment with neonatal mortality was found in Dominican Republic (OR: 3.51, CI 1.12 to 10.92); the association with infant mortality was strongest in Dominican Republic (OR: 2.74, 1.07– 6.97), whereas the association with under-5 mortality was strongest in Dominican Republic (OR: 3.18, CI 1.32 to 7.66). Nevertheless, there were variations in the associations of women empowerment with the three child mortality outcomes across the countries. In some countries, low ILWEI was associated with a lower risk of infant, under-5 and child mortality compared with high ILWEI, whereas in other cases, the associations not statistically significant. The metaanalysis of the effect of low ILWEI on neonatal, infant and under-5 mortality showed clear and consistent associations for all the threemortality outcomes (figure 3A–C). Low ILWEI status of a woman increased the risk of the child dying within the first 28 days of life (OR: 1.18, 95% CI 1.14 to 1.22), before the first birthday (OR 1.12, 95% CI 1.08 to 1.17) or before the fifth birthday (OR: 1.12, 95% CI 1.07 to 1.18) compared with the child of a woman with high ILWEI. However, there were variations in the associations of women empowerment with the three child mortality outcomes across the regions. In most regions, low ILWEI was associated with a higher risk of infant, under-5 and child mortality compared with high ILWEI. On the other hand, in a few regions, low ILWEI was associated with a lower risk of infant, under-5 and child mortality compared with high ILWEI, whereas in other cases, the associations were not statistically significant. Furthermore, there was moderate or no heterogeneity in the effects across regions. Scatter plots of the correlation of PLWEI are presented in figure 4A–C. Overall, the higher the empowerment of a woman the less likelihood of her child dying as a neonate, an infant or a child under-5 years of age (figure 4A–C). on April 1, 2020 by guest. Protected by copyright.http://gh.bmj.com/BMJ Glob Health: first published as 10.1136/bmjgh-2019-001558 on 9 January 2020. Downloaded from DokuDT, etal. BMJ Global Health 2020;5:e001558. doi:10.1136/bmjgh-2019-001558 7 BMJ Global Health Figure 2 (A) Metaanalysis of the association of low ILWEI with neonatal mortality. ORs and their 95% CIs adjusted for maternal age, wealth quintile, BMI, parity and partner’s education. Seven countries (Armenia, Indonesia, Kyrgyz Republic, Moldova, Philippines, Ukraine and Nicaragua) were excluded in the analysis due to fewer or no cases of neonatal mortality per the categories of the independent variable (low ILWEI). (B) Metaanalysis of the association of low ILWEI with infant mortality. ORs and their 95% CIs adjusted for maternal age, wealth quintile, BMI, parity and partner’s education. Seven countries (Armenia, Indonesia, Kyrgyz Republic, Moldova, Philippines, Ukraine and Nicaragua) were excluded in the analysis due to fewer or no cases of infant mortality per the categories of the independent variable (low ILWEI). (C) Metaanalysis of the association of low ILWEI with under-5 mortality. ORs and their 95% CIs adjusted for maternal age, wealth quintile, BMI, parity and partner’s education. Seven countries (Armenia, Indonesia, Kyrgyz Republic, Moldova, Philippines, Ukraine and Nicaragua) were excluded in the analysis due to fewer or no cases of under-5 mortality per the categories of the independent variable (low ILWEI). BMI, body mass index; ILWEI, individuallevel women’s empowerment index. on April 1, 2020 by guest. Protected by copyright.http://gh.bmj.com/BMJ Glob Health: first published as 10.1136/bmjgh-2019-001558 on 9 January 2020. Downloaded from 8 DokuDT, etal. BMJ Global Health 2020;5:e001558. doi:10.1136/bmjgh-2019-001558 BMJ Global Health Figure 3 Metaanalysis of the association of low ILWEI with (A) under-5 mortality, (B) infant mortality and (C) neonatal mortality, adjusted for maternal age, wealth quintile, BMI, parity and partner’s education by the regions. The associations are presented in ORs and their 95% CIs for each region in the pooled data. BMI, body mass index; ILWEI, individuallevel women’s empowerment index. dIsCussIon Our study shows that women’s empowerment was low in many of the LMICs studied. Four out of every 10 women did not have autonomy over their own healthcare decision making, only onefifth had autonomy in all household decision making and just about half on April 1, 2020 by guest. Protected by copyright.http://gh.bmj.com/BMJ Glob Health: first published as 10.1136/bmjgh-2019-001558 on 9 January 2020. Downloaded from DokuDT, etal. BMJ Global Health 2020;5:e001558. doi:10.1136/bmjgh-2019-001558 9 BMJ Global Health Figure 4 Scatter plot of PLWEI with (A) under-5 mortality, (B) infant mortality and (C) neonatal mortality per 1000 live births. The regression line shows the line of best fit. PLWEI, populationlevel women’s empowerment index. rejected domestic violence against women for any reason. Furthermore, it was found that both ILWEI and PLWEI were associated with higher odds of neonatal, infant and under-5 mortality in LMICs. Our findings from the metaanalysis provide evidence that women’s empowerment has the potential to reduce preventable neonatal, infant and under-5 mortality in several LMICs and across the regions. Women’s empowerment is a key global developmental agenda (SDG 5), and while an end in itself, also a means to advance the other SDGs, including those related to child health and survival (SDG 3). Our findings of significant associations between women’s empowerment and child survival are consistent with earlier studies, which also found associations of women’s empowerment with child health indicators including immunisation completion rate and undernutrition.17 18 Women’s deprivation to access healthcare or their inability to make a decision regarding healthcare can have a direct bearing on their health and their children. In most LMICs, women are the main caregivers of children. Less empowered women may therefore not be able to make key decisions regarding practices affecting their health and their children’s, such as compliance with vaccination schedules or the provision of recommended nutrition plans for their children, even if the means were available. Less empowered women are also unlikely to seek appropriate care during childhood illnesses.28 Elimination of preventable child deaths in LMICs also requires the availability of reliable information on risk factors and the patterns of distribution across the region to inform evidencebased interventions. Previous studies have mostly explored the immediate causes of child mortality but little empiric information is available on the contribution of underlying causes such as the role of women’s empowerment, which are preventable and less costintensive.8 11 Our findings suggest that enhancing women’s empowerment can avert additional preventable deaths among neonatal, infants and under-5 in LMICs. This can be done by supporting girls’ and women’s education. It is known that educated women have healthier children who live longer and are more likely to educate their offspring than uneducated women.29 Education therefore is one critical women’s empowerment tool. In addition, there is the need to provide training for women to acquire the necessary skills and knowledge to manage their own farms, small and large businesses. This will empower them economically to provide for themselves and their families. Such training should take into consideration the social norms and the values of each component of the ILWEI and PLWEI in specific countries. Apart from women’s empowerment, other important factors are such as better access to maternal and child healthcare, better access to nutritious food and availability of quality healthcare services to less empowered women, particularly in rural settings is emphasised. These strategies can contribute to improving the health of women and those of their children. Furthermore, women should be encouraged to participate in local and national governance to ensure that women have a voice in the allocation of resources for the benefit of women and society. The multidimensionality on April 1, 2020 by guest. Protected by copyright.http://gh.bmj.com/BMJ Glob Health: first published as 10.1136/bmjgh-2019-001558 on 9 January 2020. Downloaded from